Author(s):
Nikunja Kishor Mishra, Jyotirmayee Behera, Uma Mudi, Amiyakanta Mishra, Ranjan Kumar Jena
Email(s):
montu.mph@gmail.com
DOI:
10.52711/0974-360X.2025.00844 
Address:
Nikunja Kishor Mishra*, Jyotirmayee Behera, Uma Mudi, Amiyakanta Mishra, Ranjan Kumar Jena
College of Pharmaceutical Sciences, Puri (Affiliated to Odisha University of Health Sciences, Bhubaneswar), Baliguali, Puri - Konark Marine Drive Road, Puri, Odisha, India – 752004.
*Corresponding Author
Published In:
Volume - 18,
Issue - 12,
Year - 2025
ABSTRACT:
Paederia foetida is recognized as ‘skunkvine’ in English, which is having a varied pharmacological importance in therapeutic purpose. Methanolic extract of leaves of P. foetida was administered orally to the swiss albino mice at the doses of 100, 200 and 400mg/kg for 1, 7 or 14 days. All the doses revealed a significant reduction (P = 0.01) in immobility time in a dose-dependent manner compared to the vehicle control group in tail suspension and forced swimming test respectively. A significant increase in locomotor activity (P = 0.01) was observed at all dose levels following oral administration of the extract, compared to the vehicle control group. However, the extract at a dose of 400mg/kg revealed the greatest reduction in immobility time in both the tail suspension and forced swimming tests, as well as an increase in locomotor activity in mice. These results demonstrated that the methanolic extract of P. foetida leaves possesses antidepressant activity.
Cite this article:
Nikunja Kishor Mishra, Jyotirmayee Behera, Uma Mudi, Amiyakanta Mishra, Ranjan Kumar Jena. Investigation of the Antidepressant Effect of Paederia foetida L. (Rubiaceae) in Methanolic Extract using a Mice Model. Research Journal Pharmacy and Technology. 2025;18(12):5850-4. doi: 10.52711/0974-360X.2025.00844
Cite(Electronic):
Nikunja Kishor Mishra, Jyotirmayee Behera, Uma Mudi, Amiyakanta Mishra, Ranjan Kumar Jena. Investigation of the Antidepressant Effect of Paederia foetida L. (Rubiaceae) in Methanolic Extract using a Mice Model. Research Journal Pharmacy and Technology. 2025;18(12):5850-4. doi: 10.52711/0974-360X.2025.00844 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-12-34
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