Author(s):
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare
Email(s):
avinashgunjal4247@gmail.com
DOI:
10.52711/0974-360X.2025.00851 
Address:
Avinash A. Gunjal*, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare
Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 12,
Year - 2025
ABSTRACT:
Background and Objectives: L-carnitine (LC) is essential for energy production and the breakdown of fatty acids in mammals, plants, and specific bacteria. LC is known for its anti-inflammatory and antioxidant activities. The primary goal of this investigation was to examine the potential of L-carnitine L-tartrate (LCLT) as a supplement in treating hemorrhoids by using the model of Croton oil-induced hemorrhoid. Materials and Methods: LCLT was procured from Sigma Aldrich, USA. Hemorrhoids were created in the anorectal region of the experimental rats using the Croton oil-induced hemorrhoid model. Subsequently, the rats were treated with LCLT (300 and 500 mg/kg) and a standard medication Pilex granules (400 mg/kg), for a period of 7 days. On the 7th day, after 1 hour of treatment anti-hemorrhoidal potential was evaluated by examining the severity score, Evans blue (EB) dye exudation, rectoanal coefficient (RAC), cytokines profiling, and histopathology of anorectal tissue. Results: Supplementation with LCLT significantly reduced the severity score, Evans blue exudation, recto-anal coefficient, and cytokines like PG-E2, TNF-a, IL-6, and MMP-3. Additionally, histopathological examination showed a marked reduction in inflammation, congestion, and mononuclear cell (MNC) infiltration in anorectal tissue. Conclusion: This study demonstrated that LCLT can be used as a supplement to treat hemorrhoids because of its anti-inflammatory and antioxidant activities.
Cite this article:
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare. Preclinical Evaluation of Anti-hemorrhoidal Activity of L-carnitine L-tartrate (LCLT) via Stimulation of Anti-inflammatory and Antioxidant Activity in Croton Oil-induced Hemorrhoid Model. Research Journal Pharmacy and Technology. 2025;18(12):5891-8. doi: 10.52711/0974-360X.2025.00851
Cite(Electronic):
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare. Preclinical Evaluation of Anti-hemorrhoidal Activity of L-carnitine L-tartrate (LCLT) via Stimulation of Anti-inflammatory and Antioxidant Activity in Croton Oil-induced Hemorrhoid Model. Research Journal Pharmacy and Technology. 2025;18(12):5891-8. doi: 10.52711/0974-360X.2025.00851 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-12-41
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