Author(s):
Jasjeet Kaur, Gurvinder S. Sodhi
Email(s):
gssodhi@sgtbkhalsa.du.ac.in
DOI:
10.52711/0974-360X.2025.00874 
Address:
Jasjeet Kaur1, Gurvinder S. Sodhi2*
1Department of Chemistry, Shaheed Rajguru College of Applied Sciences for Women (University of Delhi) Vasundhara Encleve, Delhi - 110096, India.
2Department of Chemistry, S.G.T.B. Khalsa College, University of Delhi, Delhi - 110007, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 12,
Year - 2025
ABSTRACT:
Organometallic derivatives of mercury(II) having the composition, p-MeC6H4HgL1 (I), p-MeC6H4HgL2 (II), p-MeOC6H4HgL2 (III), p-NO2C6H4HgL3 (IV), p-MeOC6H4L4 (V) and p-NO2C6H4HgL4 (VI) [L1=deprotonated 6-mercaptopurine, L2=deprotonated 6-thioguanine, HL3=deprotonated 5-fluorouracil, L4=phenyldithiocarbazate unit] were synthesized and characterized. Their composition and has been confirmed by elemental analysis, while their purity has been gauged by TLC. Conductance measurements reveal the non-electrolyte nature of the complexes. The bidentate bonding modes of the coordinating groups and the stoichiometry of the complexes has been ascertained by spectral studies. From thermogravimetric analysis the relative lability of the complexes has been determined. The complexes have been tested against L 1210 leukemia cells. The disparity in anti-cancer activity has been correlated with the structure of the analogues. The 5-fluorouracil complex (IV) has the lowest inhibitory concentration and the highest kinetic lability.
Cite this article:
Jasjeet Kaur, Gurvinder S. Sodhi. Anti-Cancer Activity of some Organomercury (II) Complexes: Establishment of Structure-Activity Relationships. Research Journal Pharmacy and Technology. 2025;18(12):6049-2. doi: 10.52711/0974-360X.2025.00874
Cite(Electronic):
Jasjeet Kaur, Gurvinder S. Sodhi. Anti-Cancer Activity of some Organomercury (II) Complexes: Establishment of Structure-Activity Relationships. Research Journal Pharmacy and Technology. 2025;18(12):6049-2. doi: 10.52711/0974-360X.2025.00874 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-12-64
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