Author(s):
Vandana, Hema Arya, Koushal Dhamija, Preeti Singh, Gautam Kumar
Email(s):
preetisingh01144@gmail.com , drgautam9265@gmail.com
DOI:
10.52711/0974-360X.2025.00161 
Address:
Vandana1, Hema Arya1, Koushal Dhamija2, Preeti Singh1*, Gautam Kumar1,3*
1Department of Pharmacy, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh-201310, India.
2Department of Pharmaceutics, Lloyd Institute of Management and Technology, Knowledge Park II, Greater Noida, Uttar Pradesh - 201306, India.
3Department of Pharmacy, ApeejayStya University, Sohna - Palwal Road, Sohna, Gurugram, Haryana -122103, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by persistent joint inflammation, leading to severe disability and increased mortality rates. Fenugreek, known for its anti-arthritic effects, demonstrates promise in retarding RA onset and progression. However, challenges like poor bioavailability and limited target specificity hinder its therapeutic utility. To circumvent these limitations, transdermal delivery systems, notably transferosomes, offer a viable solution. This study aimed to formulate a transferosomal gel incorporating Trigonella foenum-graecum (TFG) extract, employing the thin-film hydration technique. Evaluation parameters encompassed stability, zeta potential, particle size, entrapment efficiency, and deformability. The synthesized transferosomes were integrated into Carbopol gel to enhance ease of application and prolong skin retention. Comparative analyses with conventional gel assessed parameters such as consistency, transparency, viscosity, and pH. Experimental findings revealed successful entrapment of TFG extract (63.69±3.20% w/w) within transferosomes, exhibiting favorable particle size (269.20±1.20nm) and deformability (23.71±0.92). Skin penetration kinetics demonstrated a gradual increase in TFG extract concentration over time, with TFG-extract-loaded transferosomal gel exhibiting the highest concentration among formulations at all-time points. The stability studies indicated the prolonged stability of the TFG-transferosomes in gel formulations. In conclusion, the developed TFG extract-loaded transferosomal gel presents a promising strategy for improved transdermal delivery, offering potential therapeutic benefits over conventional formulations in RA management.
Cite this article:
Vandana, Hema Arya, Koushal Dhamija, Preeti Singh, Gautam Kumar. Preparation, Characterization and Ex vivo Evaluation of Trigonellafoenum-gracium seeds extract-loaded Transferosomal gel for the Treatment of Rheumatoid Arthritis. Research Journal Pharmacy and Technology. 2025;18(3):1118-7. doi: 10.52711/0974-360X.2025.00161
Cite(Electronic):
Vandana, Hema Arya, Koushal Dhamija, Preeti Singh, Gautam Kumar. Preparation, Characterization and Ex vivo Evaluation of Trigonellafoenum-gracium seeds extract-loaded Transferosomal gel for the Treatment of Rheumatoid Arthritis. Research Journal Pharmacy and Technology. 2025;18(3):1118-7. doi: 10.52711/0974-360X.2025.00161 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-3-22
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