Author(s):
Shinta Wijayanti, Endah Mardiati, Ani Melani Maskoen, Ganesha Wandawa, Oryce Zahara, Ivan A Halim
Email(s):
shintawijayanti21@gmail.com
DOI:
10.52711/0974-360X.2025.00175 
Address:
Shinta Wijayanti1,2*, Endah Mardiati1, Ani Melani Maskoen3, Ganesha Wandawa4, Oryce Zahara5, Ivan A Halim2,
1Department of Orthodontics, Faculty of Dentistry, Universitas Padjadjaran, Jawa Barat, Indonesia.
2Doctoral Candidate, Faculty of Dentistry, Universitas Padjadjaran, Jawa Barat, Indonesia.
3Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Jawa Barat, Indonesia.
4Department of Orthodontics, Faculty of Dentistry, Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia.
5Department of Orthodontics, Faculty of Dentistry, Universitas Andalas, Sumatera Barat, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
In orthodontic therapy, efficient tooth movement is essential for aesthetics and occlusion function, so accelerating tooth movement is ideal. Hyperbaric oxygen treatment (HBOT) and Myrmecodia pendans (M. pendans) may speed up tooth movement by modulating biological processes. The research to assess the efficacy of HBOT and M. pendans ethanol extract in accelerating incisive tooth movement during orthodontic therapy, examining changes in osteoclasts, osteoblasts, and TNF-a/TGF-ß gene expression. Twenty-five orthodontic model animals were tested for incisive distance using calipers, H&E staining of osteoblasts and osteoclasts, and RT-PCR for TNF-a and TGF-ß gene expression. Incisive tooth movement improved in the T2 (2.78±0.10) and T3 (2.78±0.08) groups. Osteoclast cells performed best (mm2) in the T4 (44.36±7.14) and T3 (45.84±8.34) groups. The T2 and T4 groups significantly impact bone reabsorption (osteoblast) (50.06±1.83 and 44.26±6.26), respectively. TNF-a gene expression was ideal in the T4 group (0.47±0.20), while TGF-ß gene expression was highest in the T3 (68.45±2.57) and T2 (44.87±6.71) groups. Performance study revealed a 60% influence of TNF-a and TGF-ß genes, with a 20% impact on incisor tooth, osteoclast cell, and osteoblast movement characteristics. The combination of hyperbaric oxygen therapy and the application of M. pendans shows significant potential in accelerating incisive tooth movement in orthodontic treatment.
Cite this article:
Shinta Wijayanti, Endah Mardiati, Ani Melani Maskoen, Ganesha Wandawa, Oryce Zahara, Ivan A Halim. Effects of Hyperbaric Oxygen and Myrmecodia pendans Therapy on Alveolar Bone Remodeling in Orthodontic Treatment. Effects of Hyperbaric Oxygen and Myrmecodia pendans Therapy on Alveolar Bone Remodeling in Orthodontic Treatment. Research Journal of Pharmacy and Technology. 2025;18(3):1209-7. doi: 10.52711/0974-360X.2025.00175
Cite(Electronic):
Shinta Wijayanti, Endah Mardiati, Ani Melani Maskoen, Ganesha Wandawa, Oryce Zahara, Ivan A Halim. Effects of Hyperbaric Oxygen and Myrmecodia pendans Therapy on Alveolar Bone Remodeling in Orthodontic Treatment. Effects of Hyperbaric Oxygen and Myrmecodia pendans Therapy on Alveolar Bone Remodeling in Orthodontic Treatment. Research Journal of Pharmacy and Technology. 2025;18(3):1209-7. doi: 10.52711/0974-360X.2025.00175 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-3-36
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