Author(s):
IKh Shaykhutdinov, IM Bairikov, AA Shmelev, AV Sokolov
Email(s):
i.h.shajhutdinov@samsmu.ru
DOI:
10.52711/0974-360X.2025.00191 
Address:
IKh Shaykhutdinov1*, IM Bairikov2, AA Shmelev3, AV Sokolov1
1Laboratory New Medical Materials and Technologies, Professional Center for Education and Research in Genetic and Laboratory Technologies, Samara State Medical University, Ulitsa Chapaevskaya 89, Samara, 443099, Russian Federation.
2Department Oral and Maxillofacial Surgery, Samara State Medical University, Ulitsa Chapaevskaya 89, Samara, 443099, Russian Federation.
3Department Chemistry of Institute of pharmacy, Samara State Medical University, Ulitsa Chapaevskaya 89, Samara, 443099, Russian Federation.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
Metal organic frameworks (MOFs) have a promising application for targeted delivery and controlled release of drugs. The aim of this work was to study the potential of MIL-101 (Fe) for prolonged drug release. In this study, we synthesized MIL-101(Fe) using the hydrothermal method. This MOF has a high surface area, acceptable pore aperture sizes, polymer components (iron and terephthalic acid) have low toxicity, in addition, this material is capable of biodegradation. For the above reasons, MIL-101(Fe) was chosen by us as the carrier of the medicinal substance. Metronidazole is encapsulated (10% by weight) in MOF. The synthesized materials were characterized by the methods of powder X-ray diffractometry, porosimetry and scanning electron microscopy. These methods confirmed the loading of the drug substance into the pores of MIL-101(Fe), and also showed the absence of the effect of metronidazole encapsulation on the structure of the MOF. In this paper, we conducted a study on the release of metronidazole from MIL-101(Fe) in water and model biological fluids and showed that the complete release of metronidazole in artificial saliva was observed for 7.5 hours, with a cumulative release of 92.74±2.04%, in serum - after 9 hours, with a cumulative release of 80.36±1.57%. The selectivity of metronidazole release from MIL-101(Fe) in various media was revealed.
Cite this article:
IKh Shaykhutdinov, IM Bairikov, AA Shmelev, AV Sokolov. Metronidazole Loading in MIL-101(Fe) and Investigation of release in various body fluids. Research Journal of Pharmacy and Technology. 2025;18(3):1317-3. doi: 10.52711/0974-360X.2025.00191
Cite(Electronic):
IKh Shaykhutdinov, IM Bairikov, AA Shmelev, AV Sokolov. Metronidazole Loading in MIL-101(Fe) and Investigation of release in various body fluids. Research Journal of Pharmacy and Technology. 2025;18(3):1317-3. doi: 10.52711/0974-360X.2025.00191 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-3-52
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