Author(s):
Sri Ningsih, Idah Rosidah, Kurnia Agustini, Prasetyawan Yunianto, Kyu Jong Lee, Julham Efendi, Nurhadi
Email(s):
srin002@brin.go.id
DOI:
10.52711/0974-360X.2025.00449 
Address:
Sri Ningsih1*, Idah Rosidah1, Kurnia Agustini1, Prasetyawan Yunianto1, Kyu Jong Lee2, Julham Efendi1, Nurhadi1
1Research Center for Pharmaceutical Ingredient and Traditional Medicine. BRIN. LAPTIAB Building No 610, Puspiptek Serpong Area, South Tangerang, Banten, Indonesia.
2International Biological Material Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Diabetes mellitus (DM) is a metabolic disturbance disease indicated, by high glucose levels, with its prevalence increasing every year. This study aimed to evaluate the lowering blood glucose efficacy of the proportionate combination of mulberry and cinnamon extracts (formula extract). A total of 24 male Sprague-Dawley rats with hyperglycemia induced using a combination of high-fat diet (HFD) and streptozotocin (STZ) were divided into 5 groups of 4 rats each, namely, Dose 1 group (125mg/kg bw), Dose 2 group (250mg/kg bw), Dose 3 group (500 mg/kg bw), Control group (metformin 45mg/kg bw), and Model group (carrier). The Normal group was given a carrier. The formula extract was orally administered for 21 days, and fasting blood glucose levels were evaluated before the sample administration, on the 4th, 7th, and 21st days after sample administration. This study demonstrated that the administration of formula extract, especially at doses 1 and dose 3, significantly reduced fasting glucose levels (p<0.05) compared to the DM model animals. Formula extract standardization demonstrated that it contained alkaloid, flavonoid, saponin, tannin, coumarin, and steroid compound groups, and the total phenolic level was 1.39±0.07% and fulfilled the specific characterization of the extract requirement as well. In conclusion, the formula extract had the potential to be developed as a blood glucose-lowering agent.
Cite this article:
Sri Ningsih, Idah Rosidah, Kurnia Agustini, Prasetyawan Yunianto, Kyu Jong Lee, Julham Efendi, Nurhadi. Lowering Blood Glucose Activity of the combined Mulberry (Morus alba L.) and Cinnamon (Cinnamomun burmannii Nees and T.Nees) extracts in diabetic rats. Research Journal of Pharmacy and Technology. 2025;18(7):3127-2. doi: 10.52711/0974-360X.2025.00449
Cite(Electronic):
Sri Ningsih, Idah Rosidah, Kurnia Agustini, Prasetyawan Yunianto, Kyu Jong Lee, Julham Efendi, Nurhadi. Lowering Blood Glucose Activity of the combined Mulberry (Morus alba L.) and Cinnamon (Cinnamomun burmannii Nees and T.Nees) extracts in diabetic rats. Research Journal of Pharmacy and Technology. 2025;18(7):3127-2. doi: 10.52711/0974-360X.2025.00449 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-7-29
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