Author(s):
Alpha Fardah Athiyyah, Andy Darma, Khadijah Rizky Sumitro, Reza Gunadi Ranuh, Rabiatul Adawiah, Wibi Riawan, Widjiati Widjiati, Subijanto Marto Sudarmo
Email(s):
andy.darma@fk.unair.ac.id
DOI:
10.52711/0974-360X.2025.00508 
Address:
Alpha Fardah Athiyyah1,2, Andy Darma1,2*, Khadijah Rizky Sumitro1,2, Reza Gunadi Ranuh1,2, Rabiatul Adawiah1,2, Wibi Riawan3, Widjiati Widjiati4, Subijanto Marto Sudarmo1,2
1Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
3Department of Biomolecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
4Department of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
Gastric mucosal injury is a common condition affecting the gastrointestinal tract that is frequently caused by the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. In this study, we determined the effect of various doses of ibuprofen on gastric mucosal damage in rat models. Male Wistar rats (n = 32) aged 12 weeks with body weights ranging from 200-250g were randomly assigned to two experimental doses of ibuprofen: 200mg/kg body weight (BW) and 300mg/kg BW for 1 day. Specific doses of ibuprofen in sterile water were orally administered to the rats on day 0, followed by treatment with distilled water. Rats were euthanized at 1-, 3-, 5-, and 7-days post treatment and gastric mucosa damage was assessed microscopically. Gastric mucosal damage was assessed based on five parameters: inflammation, epithelial defect, oxyntic atrophy, hemorrhage, and submucosal edema, using Roger’s modified (2012) histology activity index (HAI). Ibuprofen treatment at 200 and 300mg/kg BW significantly exacerbated gastrointestinal hemorrhage at 1-, 3-, 5- and 7-days post administration. Both doses can cause gastric mucosal injury on the first day post-treatment and persist longer at higher doses. Conclusively, administration of ibuprofen at 200mg/kg BW induced gastric mucosal damage, which was exacerbated at a higher dose of 300mg/kg BW.
Cite this article:
Alpha Fardah Athiyyah, Andy Darma, Khadijah Rizky Sumitro, Reza Gunadi Ranuh, Rabiatul Adawiah, Wibi Riawan, Widjiati Widjiati, Subijanto Marto Sudarmo. Comparative Analysis of Gastric Mucosal damage in Wistar Rats Subjected to Varying Doses of Ibuprofen. Research Journal Pharmacy and Technology. 2025;18(8):3530-6. doi: 10.52711/0974-360X.2025.00508
Cite(Electronic):
Alpha Fardah Athiyyah, Andy Darma, Khadijah Rizky Sumitro, Reza Gunadi Ranuh, Rabiatul Adawiah, Wibi Riawan, Widjiati Widjiati, Subijanto Marto Sudarmo. Comparative Analysis of Gastric Mucosal damage in Wistar Rats Subjected to Varying Doses of Ibuprofen. Research Journal Pharmacy and Technology. 2025;18(8):3530-6. doi: 10.52711/0974-360X.2025.00508 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-11
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