Author(s):
Shakeel Memon, Aney Joice, Dilnawaz Pathan, Aasia Patel
Email(s):
memon.shakeel@gmail.com
DOI:
10.52711/0974-360X.2025.00513 
Address:
Shakeel Memon1, Aney Joice1, Dilnawaz Pathan2, Aasia Patel1*
1Department of Pharmaceutics, M.C.E. Society’s Allana College of Pharmacy, Azam Campus, Camp, Pune.
2HOD, Department of Pharmaceutics, Trinity College of Pharmacy, Pune.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
The aim of this research was to formulate extended-release Furosemide tablets using Polylacticcoglycolic acid (PLGA) and Hydroxy Propyl Methyl Cellulose (HPMC) polymers. The wet granulation method was employed in the preparation, and a 32 Response Surface Methodology (RSM) factorial design was utilized, yielding a total of nine formulations (F1 to F9). The formulations were then subjected to thorough evaluation, which included assessing their physical parameters such as weight variation, hardness, friability, and thickness, as well as drug content and in vitro release profiles. All formulations conformed to the standards set forth by the Pharmacopoeia. The in-vitro dissolution experiments were performed utilizing the USP dissolution apparatus type-II (paddle method). Analyzing the dissolution profiles, formulation F1 emerged as the most optimal, showing the best extended-release profile.
Cite this article:
Shakeel Memon, Aney Joice, Dilnawaz Pathan, Aasia Patel. Formulation Development for ER Tablets of Furosemide with Statistical Optimization and Characterization by RSM Factorial approach. Research Journal Pharmacy and Technology. 2025;18(8):3565-1. doi: 10.52711/0974-360X.2025.00513
Cite(Electronic):
Shakeel Memon, Aney Joice, Dilnawaz Pathan, Aasia Patel. Formulation Development for ER Tablets of Furosemide with Statistical Optimization and Characterization by RSM Factorial approach. Research Journal Pharmacy and Technology. 2025;18(8):3565-1. doi: 10.52711/0974-360X.2025.00513 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-16
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