Author(s):
Suvendu Kumar Sahoo, Rabinarayan Parhi
Email(s):
drssahoo.research@gmail.com , rabi59bls623@gmail.com
DOI:
10.52711/0974-360X.2025.00526 
Address:
Suvendu Kumar Sahoo1, Rabinarayan Parhi2
1Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, Barasat, Kolkata - 700126, West Bengal, India.
2Department of Pharmaceutical Sciences, Assam University (A Central University), Silchar - 788011, Cachar, Assam, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
The current study set out to assess the impact of microsphere formulation variables on the drug release and entrapment efficiency of a model medication, amlodipine besylate. A three-factor, three-level Box-Behnken design was used to examine the main and interaction impacts of several independent formulation factors, including the ratio of drug to polymer, the concentration of surfactant, and the amount of acetone. Entrapment efficiency (EE) and cumulative percentage drug release (CPR) were the dependent variables. In order to maximise amlodipine entrapment efficiency and provide a desirable, sustained release over a 12-hour period, formulation optimisation was done. The drug release, entrapment efficiency, size, and shape of the prepared microspheres were evaluated. To explain the effect of all components and their co-linearities on the %EE and CPR of amlodipine, respectively, mathematical relationships were obtained: EE = 78.95 –1.67A+3.18B +1.50C and CPR = +81.75 –7.72A +5.15B +0.9500C +2.68AB –0.1100AC –0.1800BC –11.79A2 –1.14B2 –0.1775C2 (r2 = 0.9970). A new batch was made using the optimised formulation, and there was a strong agreement between the observed and expected values of CPR and EE. We were able to understand the effect of formulation parameters on the entrapment efficiency and obtain optimal and sustained drug dissolving through the use of the Box-Behnken experimental design.
Cite this article:
Suvendu Kumar Sahoo, Rabinarayan Parhi. Development and Optimization of Amlodipine besylate microspheres by 3-factor–3–level Box-Behnken design. Research Journal Pharmacy and Technology. 2025;18(8):3655-1. doi: 10.52711/0974-360X.2025.00526
Cite(Electronic):
Suvendu Kumar Sahoo, Rabinarayan Parhi. Development and Optimization of Amlodipine besylate microspheres by 3-factor–3–level Box-Behnken design. Research Journal Pharmacy and Technology. 2025;18(8):3655-1. doi: 10.52711/0974-360X.2025.00526 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-29
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