ABSTRACT:
BACKGROUND: Ginseng is one of the most significant medicinal plants that has been used for thousands of years. Ginsenosides are the major constituents of ginseng and possess low bioavailability below 5%. Hence it is necessary to enhance the bioavailability through various approaches. Ginseng's limited oral bioavailability can be overcome using fast mouth-dissolving film. AIM and OBJECTIVE: The research study aimed to formulate fast-mouth dissolving ginseng oral films and analyze the effect of various Hydroxypropyl methylcellulose (HPMC) E15, HMPC E5, and natural gums. METHOD: The solvent casting technique was employed to formulate the films. FTIR analysis was used to investigate the relationship between the polymer and Ginseng in the film formulation. The formulated films were evaluated for moisture content, surface pH, percentage drug content, thickness, disintegration time, folding endurance, and percentage elongation and in-vitro drug release. RESULT: The optimized formulation F3 showed the highest drug release of 90.89%. The formulation's drug content range was recorded between 86.23% to 94.52%. Korsmeyer-Peppas was the best-fit model from fast-dissolving film based on the in-vitro drug release kinetic model results. CONCLUSION: Ginseng mouth dissolving films may give fast action which increases the bioavailability. Mouth-dissolving film provides better patient compliance in terms of ease of administration and therapeutic effectiveness compared to commercial formulations such as instant release and orally disintegrating tablets.