Author(s):
Sourav Khawas, Soma Ghosh, Ranit Kanjilal, Kritika Modak, Milan Nandi, Wrila Chakraborty, Kishor Kumar Roy
Email(s):
roykishorkumar1998@gmail.com
DOI:
10.52711/0974-360X.2025.00550 
Address:
Sourav Khawas1, Soma Ghosh1, Ranit Kanjilal2, Kritika Modak1, Milan Nandi3, Wrila Chakraborty1, Kishor Kumar Roy1*
1Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi, Jharkhand - 834010, India.
2Flemming College of Pharmacy, Balarampur, Mouza Beralia, Baruipur, Kolkata – 700144.
3Institute of Pharmaceutical Sciences, RKDF University Ranchi, Jharkhand - 834004.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
Background: An adverse stimulus's biological reaction is inflammation and a key factor in the pathogenesis of various diseases. Lycopene, a potent antioxidant found abundantly in watermelon (Citrullus lanatus), has demonstrated significant anti-inflammatory properties. This study aims to formulate a lycopene-based emulgel from watermelon and assess its anti-inflammatory properties in Wistar rats. Materials and methods: Lycopene was extracted from watermelon. A stable emulgel formulation was developed, combining the benefits of emulsions and gels for effective topical delivery. Using well-established experimental models, the emulgel's anti-inflammatory effectiveness was accessed. Results and discussion: Results indicated that the lycopene-based emulgel significantly reduced inflammation in treated rats, as evidenced by decreased edema and reduced levels of pro-inflammatory cytokines. The mechanisms underlying these effects include the antioxidant activity of lycopene, inhibition of pro-inflammatory cytokines, suppression of the NF-?B pathway, and modulation of enzymatic activity. Additionally, the emulgel formulation ensured enhanced skin penetration and localized action, maximizing therapeutic efficacy while minimizing systemic exposure. Conclusion: In conclusion, the lycopene-based emulgel formulated from watermelon exhibits promising anti-inflammatory activity and offers a potential therapeutic approach for managing inflammatory conditions. Further studies are warranted to explore its clinical applications and long-term safety.
Cite this article:
Sourav Khawas, Soma Ghosh, Ranit Kanjilal, Kritika Modak, Milan Nandi, Wrila Chakraborty, Kishor Kumar Roy. Formulation of Lycopene Based Emulgel from Watermelon and Evaluation of Anti-inflammatory Activity on Wister Rats. Research Journal Pharmacy and Technology. 2025;18(8):3824-8. doi: 10.52711/0974-360X.2025.00550
Cite(Electronic):
Sourav Khawas, Soma Ghosh, Ranit Kanjilal, Kritika Modak, Milan Nandi, Wrila Chakraborty, Kishor Kumar Roy. Formulation of Lycopene Based Emulgel from Watermelon and Evaluation of Anti-inflammatory Activity on Wister Rats. Research Journal Pharmacy and Technology. 2025;18(8):3824-8. doi: 10.52711/0974-360X.2025.00550 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-53
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