Author(s):
Zahara Meilawaty, Agustin Wulan Suci D., Amandia Dewi Permana Shita, Sofinatur Rohibah
Email(s):
agustinwulan.drg@unej.ac.id
DOI:
10.52711/0974-360X.2025.00559 
Address:
Zahara Meilawaty1, Agustin Wulan Suci D.1*, Amandia Dewi Permana Shita1,Sofinatur Rohibah2
1Department of Dentistry-Biomedical Science, Oral Pathology and Maxillofacial Faculty of Dentistry Universitas Jember.
2Bachelor of Dental Surgery, Faculty of Dentistry Universitas, Jember.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
Background: Periodontitis is an inflammation of the teeth supporting tissues with a high prevalence in Indonesia caused by Porphyromonas gingivalis. P.gingivalis is a periodontal pathogen often associated with systemic disorders. P. gingivalis and its products carried by the systemic circulation to reach the liver will trigger the inflammatory process and cause inflammatory cell infiltration. Continuous inflammation can eventually lead to chronic liver injury. Periodontitis treatment can be done by giving metronidazole. However, it comes with side effects. One alternative natural plant that provides antibacterial and anti-inflammatory effects is cassava leaves. Objective: To determine the potential of cassava leaf extract (Manihot esculenta Crantz.) in reducing the number of chronic inflammatory cells in the liver of periodontitis rat models. Methods: This research is an experimental laboratory with a posttest-only control group design. The research sample was male Wistar rats divided into four groups: baseline, periodontitis group which was given aquadest, metronidazole, and cassava leaf extract. A rat model of P. gingivalis was induced with periodontitis. The rats were then euthanized, their livers were taken, and histological preparations were made with HE staining. Observation and counting of chronic inflammatory cells were performed around the central vein. The one-way ANOVA test was carried out based on the data from the research. Results: The results of the LSD test with a significance value of p<0.05 showed a significant difference between the baseline group and the treatment group. There was no significant difference between the extract group and the positive control group and between the extract group and the negative control group. Conclusion: Based on the research, it can be concluded that there was a decrease in the number of chronic inflammatory cells in the liver of periodontitis model mice treated using cassava leaf extract (Manihot esculenta Crantz).
Cite this article:
Zahara Meilawaty, Agustin Wulan Suci D., Amandia Dewi Permana Shita, Sofinatur Rohibah. Cassava leaf extract (Manihot esculenta Crantz) as Antiinflammatory to Reduce Chronic Inflammatory Cells in Rats Liver Periodontitis Model. Research Journal Pharmacy and Technology. 2025;18(8):3895-0. doi: 10.52711/0974-360X.2025.00559
Cite(Electronic):
Zahara Meilawaty, Agustin Wulan Suci D., Amandia Dewi Permana Shita, Sofinatur Rohibah. Cassava leaf extract (Manihot esculenta Crantz) as Antiinflammatory to Reduce Chronic Inflammatory Cells in Rats Liver Periodontitis Model. Research Journal Pharmacy and Technology. 2025;18(8):3895-0. doi: 10.52711/0974-360X.2025.00559 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-62
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