ABSTRACT:
Disintegration and then dissolution yield the compositions' medicinal efficacy. The proper disintegrant must be used in tablets and capsules in order to provide the best bioavailability. Disintegrants are the ingredients that break down tablets or capsules quickly into tiny pieces so they dissolve faster than they would if they didn't have them. Conversely, However, superdisintegrants, which are, as their name implies, superior to disintegrants, are compounds that speed up or assist disintegration even at low concentrations, usually 1–10% by weight in relation to the dosage unit's total weight. These are employed to boost the potency of solid dosage forms. Over the past ten years, there has been a steady increase in the market for fast-disintegrating tablets (FDTs), and the pharmaceutical sector has seen a significant expansion in this field. MDTs are solid unit Dosage forms that quickly dissolve in the mouth without the need for chewing or water. For elderly and paediatric patients who have trouble swallowing, FDTs, orally disintegrating tablets, offer benefits over traditional capsules and pills. This review describes the classification of superdisintegrants, its advantage, disadvantage, how it can be employed for preparing MDT, their mechanism of action, factors affecting disintegration and the recent development of superdisintegrants and finally application.