ABSTRACT:
Solid dispersions have garnered significant attention for their ability to enhance the dissolution rate and bioavailability of hydrophobic drugs. This comprehensive review delves into the various preparation techniques and recent technological advancements in solid dispersion technology. The article explores the different types of solid dispersions, classified based on their molecular arrangement, and discusses key practical considerations for their preparation. These include the selection of suitable carriers and methods for physicochemical characterization. This review also highlights the various carriers employed in solid dispersion preparation, their corresponding outcomes, and the underlying mechanisms driving solubility enhancement. By examining the role of carriers such as polymers, surfactants, and other excipients, we can gain a deeper understanding of how solid dispersions improve drug solubility and bioavailability. By exploring these aspects, we can unlock the full potential of solid dispersion technology and develop innovative solutions for poorly soluble drugs.
Cite this article:
Nidhi Jain, Babita Kumar. Solid Dispersion Technique: A Strategic Solution to Boost Solubility. Research Journal Pharmacy and Technology. 2025;18(8):3974-8. doi: 10.52711/0974-360X.2025.00571
Cite(Electronic):
Nidhi Jain, Babita Kumar. Solid Dispersion Technique: A Strategic Solution to Boost Solubility. Research Journal Pharmacy and Technology. 2025;18(8):3974-8. doi: 10.52711/0974-360X.2025.00571 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-74
REFERENCE:
1. Punitha S et al. Solid Dispersions: A Review. Research J. Pharm. and Tech. 2011; 4(3): 331-33.
2. K Manukonda et al. Solid Dispersions-An Approach to Enhance the Dissolution Rate of Clopidogrel Bisulphate. Asian Journal of Pharmaceutical Sciences. 2014; 4(4): 165-168.
3. Mir and Khan. Solid Dispersion: Overview of the Technology. IJPSR. 2017; 8(6): 2378-2387. doi: 10.13040/IJPSR.0975-8232.8(6).
4. 4.Ranim Alrouhayyah et al. Solid Dispersions: An Effective Technology for Improving Dissolution Kinetics of Poorly Soluble Drugs. Research Journal of Pharmacy and Technology. 2023; 16(12): 5701-6. doi: 10.52711/0974-360X.2023.00922
5. Tekade A and Narayan J. A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs. Adv Pharm Bull. 2020; 10(3): 359-369. doi: 10.34172/apb.2020.044
6. Tushar D.Sonawane and Rajesh Z. Mujoriya. Role of Hydrophilic Carrier in Solubility Enhancement. Research Journal of Pharmacy and Technology. 2016; 8(3): 173-176.
7. Nikghalb LA and Singh G. Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs. Journal of Applied Pharmaceutical Science. 2012; 2 (10): 170-175. doi: 10.7324/JAPS.2012.21031
8. Kohri N et al. Improving the oral bioavailability of Albendazole in rabbits by the solid dispersion technique. J. Pharm. Pharmacol. 1999; 51: 159-64.
9. Okimoto K et al. Dissolution mechanism and rate of solid dispersion particles of Nilvadipine with hydroxyl propyl methyl cellulose. Int. J. Pharm. 1997; 159: 85-93.
10. Sneha D. Bhore. A Review on Solid Dispersion as a Technique for Enhancement of Bioavailability of Poorly Water Soluble Drugs. Research J. Pharm. and Tech. 2014; 7(12): 1485-1491.
11. Ruba Malkawi et al. Current Trends on Solid Dispersions: Past, Present, and Future. Advances in Pharmacological and Pharmaceutical Sciences. 2022; 2022(2): 1-17. doi:10.1155/2022/5916013
12. Ahmad A. E. et al. Preparation and Evaluation of Aceclofenac Solid Dispersion by Fusion Technique and Effervescent Assisted Fusion Technique: Comparative Study. Research Journal of Pharmacy and Technology. 2023; 16(11): 5358-5. doi: 10.52711/0974-360X.2023.00868
13. Breitenbach J. Melt extrusion: From process to drug delivery technology. Eur J Pharm Biopharm. 2002; 54: 107-117.
14. Chokshi R and Hossein Z. Hot Melt Extrusion Technique: A Review. Iran J Pharm Res. 2004; 3: 3-16.
15. AV Yadav and VB Yadav. Improvement of Physicochemical properties of Mesalamine with Hydrophilic Carriers by Solid Dispersion (kneading) method. Research Journal of Pharmacy and Technology. 2008; 1(4): 422-425.
16. Jagdale S et al. Preparation and characterization of Metformin hydrochloride - Compritol 888 ATO solid dispersion. J Young Pharm 2011; 3(3): 197-204. doi: 10.4103/0975-1483.83758
17. DS Saindane et al. Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188. Research Journal of Pharmacy and Technology Research. 2009; 1(2): 162-166.
18. Nilesh S. Kulkarni et al. Physico-Chemical Evaluation and In-vitro Release Studies of Irbesartan: β-Cyclodextrin: Soluplus Ternary Inclusion Complex. Research J. Pharm. and Tech. 2014; 7(9): 987-994.
19. Hassan AS et al. Solubilization and enhancement of ex vivo vaginal delivery of progesterone using solid dispersions, inclusion complexes and micellar solubilization. Curr Drug Deliv 2018; 15(1): 110-21. doi: 10.2174/156720181466617032014 2136
20. Marques CSF et al. Solid dispersion of Praziquantel enhanced solubility and improve the efficacy of the schistosomiasis treatment. J Drug Deliv Sci Technol. 2018; 45: 124-34. doi: 10.1016/j.jddst.2018.03.009
21. Mahore J. G. et al. Solid Dispersion Technique for Solubility Improvement of Ketoconazole for Vaginal Delivery. Research J. Pharm. and Tech. 2019; 12(4): 1649-1654. doi: 10.5958/0974-360X.2019.00276.2
22. Dattatreya B Udgirkar et al. Formulation and In-vitro Evaluation of Buccoadhesive Tablets containing Ketoconazole inclusion complex with β- Cyclodextrin. Research Journal of Pharmacy and Technology. 2009; 2(2): 396-404.