Author(s):
Ajay Kumar Shukla, Vimal Kumar Yadav, Pushpendra Kumar, Aarti Tiwari, Jayanti Tiwari
Email(s):
jtiwaripharma@yahoo.com
DOI:
10.52711/0974-360X.2025.00574 
Address:
Ajay Kumar Shukla1, Vimal Kumar Yadav1, Pushpendra Kumar2, Aarti Tiwari3, Jayanti Tiwari4*
1Institute of Pharmacy, Dr Rammanohar Lohia Avadh University, Ayodhya.
2Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences Saifai Etawah, UP.
3Department of Pharmacy, Guru Ghasidas Vishwavidyalaya is a Central University in Bilaspur, Chhattisgarh, India.
4Gyan Ganga Institute of Technology and Science, Jabalpur, M.P., India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
Improving the solubility of drugs that are poorly soluble in water is a significant difficulty in pharmaceutical formulation development. To improve the solubility and rate of dissolution of pharmaceuticals, a commonly used technique called solid dispersion involves dispersing the drugs inside a hydrophilic carrier matrix. Because of their excellent environmental properties, affordability, and biocompatibility, natural gums derived from plants have garnered a lot of attention as flexible carriers in solid dispersion formulations. Natural gums that are hydrophilic and able to create films include guar gum, xanthan gum, and gum Arabic. These properties increase the surface area and improve the dissolution kinetics of the polymeric matrix by aiding in the dispersion of drug molecules throughout it. Recent advancements in the subject are also covered in the abstract, such as the use of natural gums in conjunction with specific other materials to increase the solubility and bioavailability of pharmaceuticals. Two cooperative processing methods that have showed promise in enhancing formulation stability and obtaining superior drug solubility characteristics are co-precipitation and hot melt extrusion. In order to increase the solubility of medications with limited water solubility, the current study explores the possible use of natural gums in solid dispersion systems. The paper's first part looks into solid dispersion and discusses the role that natural gums play in making medications more soluble. Moreover, improved treatment outcomes and higher patient adherence may result from the application of cutting-edge technologies and techniques meant to boost pharmaceutical solubility.
Cite this article:
Ajay Kumar Shukla, Vimal Kumar Yadav, Pushpendra Kumar, Aarti Tiwari, Jayanti Tiwari. Use of Natural Gum in Poorly Water - Soluble Drug Solid Dispersion and Solubility Enhancement. Research Journal Pharmacy and Technology. 2025;18(8):3995-0. doi: 10.52711/0974-360X.2025.00574
Cite(Electronic):
Ajay Kumar Shukla, Vimal Kumar Yadav, Pushpendra Kumar, Aarti Tiwari, Jayanti Tiwari. Use of Natural Gum in Poorly Water - Soluble Drug Solid Dispersion and Solubility Enhancement. Research Journal Pharmacy and Technology. 2025;18(8):3995-0. doi: 10.52711/0974-360X.2025.00574 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-77
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