Author(s): Saba Shaikh, Ajaj Ahmad, Shaikh Noman, Mohd Aaqib Khan, Sohail Bakkar, Shaikh Mubeen Mehmood, Momin Mohammad Kaif Mohammad Ayaz

Email(s): shaikhsaba66@gmail.com

DOI: 10.52711/0974-360X.2025.00577   

Address: Saba Shaikh, Ajaj Ahmad, Shaikh Noman, Mohd Aaqib Khan, Sohail Bakkar, Shaikh Mubeen Mehmood, Momin Mohammad Kaif Mohammad Ayaz
Anjuman-I-Islam Kalsekar Technical Campus, Navi Mumbai, Maharashtra.
*Corresponding Author

Published In:   Volume - 18,      Issue - 8,     Year - 2025


ABSTRACT:
The cosmetic industry is one of the vibrant industrial sectors as from the start of civilization people are using cosmetic products for routine body care and beauty enhancement. Different formulations are available to deliver active pharmaceutical ingredients to the site of action. But in the case of cosmetic products, the skin delivery of a drug is challenging as the skin has a lipid barrier. The evolution of liposomes has been used in the development of the drug carrier concept as a promising delivery system. Liposomes are spherical vesicles composed of phospholipids with an aqueous core that can be used as the delivery vehicle. Liposomes improve and facilitate the bioavailability of carried active components to the site of action. Traditional skincare products are difficult to absorb into the skin. However, Liposomes are used to carry the active ingredients deeper into the skin layers. Moreover, liposomes enhance the stability of active ingredient, increases dermal bioavailability, and improves the hydration of the skin.


Cite this article:
Saba Shaikh, Ajaj Ahmad, Shaikh Noman, Mohd Aaqib Khan, Sohail Bakkar, Shaikh Mubeen Mehmood, Momin Mohammad Kaif Mohammad Ayaz. Liposomes in Cosmetics: Formulation and Skin Delivery. Research Journal Pharmacy and Technology. 2025;18(8):4014-3. doi: 10.52711/0974-360X.2025.00577

Cite(Electronic):
Saba Shaikh, Ajaj Ahmad, Shaikh Noman, Mohd Aaqib Khan, Sohail Bakkar, Shaikh Mubeen Mehmood, Momin Mohammad Kaif Mohammad Ayaz. Liposomes in Cosmetics: Formulation and Skin Delivery. Research Journal Pharmacy and Technology. 2025;18(8):4014-3. doi: 10.52711/0974-360X.2025.00577   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-8-80


REFERENCES:
1.    Mohd. Yaqub Khan, Poonam Gupta, Bipin Bihari, Vineet Kumar Sharma, Irfaan Aziz. A Review- Miracle of Nanotechnology in Cosmetics. Research J. Topical and Cosmetic Sci. 2014: 5(1): Jan.–June 15-22.
2.    Nastruzzi, Claudio et al. Use and stability of liposomes in dermatological preparations. Journal of Applied Cosmetology. 1992; 11: 77-91.
3.    Dragicevic, Nina, and Howard I. Maibach, eds. Percutaneous penetration enhancers drug penetration into/through the skin: Methodology and general considerations. Springer, 2017.
4.    Reva T, Vaseem AA, Satyaprakash S, Md.khalid JA. Liposomes: The novel approach in cosmaceuticals. World J Pharm Pharm Sci. 2015; 4(6): 1616–40.
5.    Soni, Vandana, et al. Role of liposomal drug-delivery system in cosmetics. Nanobiomaterials in galenic formulations and cosmetics. William Andrew Publishing. 2016. 93-120.
6.    Lohani, Alka, and Anurag Verma. Vesicles: Potential nano carriers for the delivery of skin cosmetics. Journal of Cosmetic and Laser Therapy.  2017; 19(8): 485-493.
7.    De Leeuw, Jaap, et al. Liposomes in dermatology today. Journal of the European Academy of Dermatology and Venereology.  2009; 23(5): 505-516.
8.    Park DC, Yeo SG. Aging. Korean J Audiol. 2013; Sep; 17(2): 39-44. doi: 10.7874/kja.2013.17.2.39.  
9.    Bi, Ye, et al. Liposomal Vitamin D3 as an Anti-aging Agent for the Skin. Pharmaceutics. 2019; 11(7): 311.
10.    Ganceviciene, Ruta, et al. Skin anti-aging strategies. Dermato-Endocrinology. 2012; 4(3): 308-319.
11.    Kaur, Chanchal Deep, and Swarnlata Saraf. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation–damaged skin. Journal of Cosmetic Dermatology. 2011; 10(4): 260-265.
12.    Gupta, Nishant Kumar, and V. K. Dixit. Development and evaluation of vesicular system for curcumin delivery. Archives of Dermatological Research. 2011; 303(2): 89-101.
13.    Zhang, Chijian, et al. Glabridin liposome ameliorating UVB-induced erythema and lethery skin by suppressing inflammatory cytokine production.  Journal of Microbiology and Biotechnology. 2021; 31(4): 630.
14.    Yücel, Çiğdem, Gökçe Şeker Karatoprak, and İsmail Tuncer Değim. Anti-aging formulation of rosmarinic acid-loaded ethosomes and liposomes. Journal of Microencapsulation.  2019; 36(2): 180-191.
15.    Brotzu, Giovanni, et al. A liposome‐based formulation containing equol, dihomo‐γ‐linolenic acid and propionyl‐l‐carnitine to prevent and treat hair loss: a prospective investigation. Dermatologic Therapy. 2019; 32(1): e12778.
16.    Santos, Ana Cláudia, et al. Topical minoxidil-loaded nanotechnology strategies for alopecia. Cosmetics. 2020; 7(2): 21.
17.    El-Zaafarany, Ghada M., et al. Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: ex vivo permeation and clinical appraisal. Expert Opinion on Drug Delivery. 2021; 18(10): 1513-1522.
18.    Assuncao, D. P., et al. Liposomes containing acetyl hexapeptide-3 (argireline): preparation and evaluation of skin permeation. Lat Am J Pharm. 2018; 37: 37-41.
19.    Madan, Sumit, et al. Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies. Drug Development and Industrial Pharmacy. 2019; 45(3): 395-404.
20.    Rusu, Aura, et al. Recent advances regarding the therapeutic potential of adapalene. Pharmaceuticals. 2020; 13(9): 217.
21.    Leyden, James, Linda Stein-Gold, and Jonathan Weiss. Why topical retinoids are mainstay of therapy for acne. Dermatology and Therapy.  2017; 7: 293-304.
22.    Garg, Tarun. Current Nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. Artificial Cells, Nanomedicine, and Biotechnology. 2016; 44(1): 98-105.
23.    Kumar, Vijay, and Ajay K. Banga. Intradermal and follicular delivery of adapalene liposomes. Drug development and Industrial Pharmacy.  2016; 42(6): 871-879.
24.    Jain, Sanyog, et al. Codelivery of benzoyl peroxide and adapalene using modified liposomal gel for improved acne therapy. Nanomedicine. 2018; 13(12): 1481-1493.
25.    Zuo, Ting, et al. Cryptotanshinone-loaded cerasomes formulation: in vitro drug release, in vivo pharmacokinetics, and in vivo efficacy for topical therapy of acne. Acs Omega. 2016; 1(6): 1326-1335.
26.    Vincent, Nitha, and Vedha Hari BN. Progress in psoriasis therapy via novel drug delivery systems. Dermatology Reports.  2014; 6(1).
27.    Walunj, Manoj, et al. Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. Journal of Liposome Research. 2020; 30(1): 68-79.
28.    Bahramizadeh, Mahdiyeh, et al. Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model. International Journal of Pharmaceutics. 2019; 569: 118623.
29.    Bastonini, Emanuela, Daniela Kovacs, and Mauro Picardo. Skin pigmentation and pigmentary disorders: focus on epidermal/dermal cross-talk. Annals of Dermatology. 2016; 28(3): 279-289.
30.    Serre, C., V. Busuttil, and J‐M. Botto. Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation. International Journal of Cosmetic Science. 2018; 40(4): 328-347.
31.    Garg, Bhawna Jain, et al. Topical treatment in vitiligo and the potential uses of new drug delivery systems. Indian Journal of Dermatology, Venereology and Leprology. 2010; 76: 231.
32.    Doppalapudi, Sindhu, Shaheen Mahira, and Wahid Khan. Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo. Journal of Photochemistry and Photobiology B: Biology. 2017; 174: 44-57.
33.    Mir-Palomo, Silvia, et al. Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy. Colloids and Surfaces B: Biointerfaces. 2019; 175: 654-662.
34.    Wu, Michelle X., Ruth Antony, and Harvey N. Mayrovitz. Melasma: a condition of Asian skin. Cureus.  2021; 13(4).
35.    Ogbechie-Godec, Oluwatobi A., and Nada Elbuluk. Melasma: an up-to-date comprehensive review. Dermatology and Therapy.  2017; 7: 305-318.
36.    Engin, Cayir, and Y. Cayir. Pigmentation disorders: a short review. Pigment Disord.  2015; 2: 1000189.
37.    Sarkar, Rashmi, et al. Melasma update. Indian Dermatology Online Journal. 2014; 5(4): 426-435.
38.    Taghavi, Faezeh, et al. Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma. Journal of Cosmetic Dermatology. 2019; 18(3): 870-873.
39.    Ghafarzadeh, Masoumeh, and Ali Eatemadi. Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy. Journal of Cosmetic and Laser Therapy. 2017; 19(3): 181-187.
40.    Dhamoon, Rupinder K., Harvinder Popli, and Madhu Gupta. Novel drug delivery strategies for the treatment of onychomycosis. Pharmaceutical Nanotechnology. 2019; 7(1): 24-38.
41.    Gupta, A. K., et al. Onychomycosis: a review. Journal of the European Academy of Dermatology and Venereology. 2020; 34(9): 1972-1990.
42.    El-Badry, Mahmoud, Gihan Fetih, and Faiyaz Shakeel. Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations. Drug Delivery. 2014; 21(1): 34-43.
43.    Pandit, Jayamanti, Minakshi Garg, and Narendra Kumar Jain. Miconazole nitrate bearing ultraflexible liposomes for the treatment of fungal infection. Journal of Liposome Research. 2014; 24(2): 163-169.
44.    Perez, Ana Paula, et al. Topical amphotericin B in ultradeformable liposomes: Formulation, skin penetration study, antifungal and antileishmanial activity in vitro. Colloids and Surfaces B: Biointerfaces. 2016; 139: 190-198.
45.    Shah, Viral H., and Amee Jobanputra. Enhanced ungual permeation of terbinafine HCl delivered through liposome-loaded nail lacquer formulation optimized by QbD approach. AAPS PharmSciTech. 2018; 19(1): 213-224.
46.    Kumari, Beena, et al. Medicinal role of Cosmetic products in Beautifying of Skin. Research Journal of Pharmacy and Technology. 2024; 17(1): 433-438.



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