Author(s):
Avanish Maurya, Bhavana Dubey, Neha Mishra
Email(s):
bhavanadubey91@gmail.com
DOI:
10.52711/0974-360X.2025.00597 
Address:
Avanish Maurya1, Bhavana Dubey2*, Neha Mishra3
1Assistant Professor, Department of Pharmacy, Avadh Institute of Medical Technology and Hospital, Lucknow, Uttar Pradesh 206026.
2Associate Professor, Department of Pharmacy, Saroj Institute of Technology and management, Lucknow, Uttar Pradesh 206002.
3Associate Professor, Department of Pharmacy, Saroj Institute of Technology and Management, Lucknow, Uttar Pradesh 206002.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
In recent years, numerous pyrazole derivatives have been identified in scientific literature as potent anti-inflammatory agents. Among these, pyrazolyl sulfonamides and pyrazolyl derivatives of urea have demonstrated significant anti-inflammatory properties and the ability to inhibit p38a MAP kinase. This study aimed to determine the structures of these compounds using spectral data and evaluate their anti-inflammatory activity through in vitro assays. The anti-denaturation assay using bovine serum albumin (BSA) and the p38a MAP kinase assay were employed to screen the compounds for anti-inflammatory potential. Compounds that exhibited promising results in these initial assessments were further evaluated for their ability to reduce inflammation, induce ulcers, cause lipid damage, and suppress TNF-a. The findings highlight the therapeutic potential of these pyrazole derivatives in the treatment of inflammatory diseases and provide a basis for further development of novel anti-inflammatory agents.
Cite this article:
Avanish Maurya, Bhavana Dubey, Neha Mishra. Design, Synthesis of Novel Pyrazole Derivatives Bearing P-Amino benzene Sulfonyl Chloride Moiety with Anti-Inflammatory Activity and Exhibit Inhibitory effects against p38α MAP Kinase. Research Journal of Pharmacy and Technology. 2025;18(9):4153-7. doi: 10.52711/0974-360X.2025.00597
Cite(Electronic):
Avanish Maurya, Bhavana Dubey, Neha Mishra. Design, Synthesis of Novel Pyrazole Derivatives Bearing P-Amino benzene Sulfonyl Chloride Moiety with Anti-Inflammatory Activity and Exhibit Inhibitory effects against p38α MAP Kinase. Research Journal of Pharmacy and Technology. 2025;18(9):4153-7. doi: 10.52711/0974-360X.2025.00597 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-9-17
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