Author(s):
Vikas Sharma, Sandeep Kumar, Rahul Kaushik, Shaivi Parashar
Email(s):
vksharma94575@gmail.com
DOI:
10.52711/0974-360X.2025.00632 
Address:
Vikas Sharma1,2*, Sandeep Kumar1, Rahul Kaushik2, Shaivi Parashar2
1School of Pharmacy, Sharda University, Plot No 32,34, Knowledge Park III, Greater Noida, Uttar Pradesh, India 201310.
2Metro College of Health Sciences and Research, Knowledge Park III, Greater Noida, Uttar Pradesh, India 201310.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
This study investigates the anticancer and antioxidant potential of a novel phytochemical combination of eugenol, a natural compound extracted from cloves, and Sanguinarine, a flavonoid from Sanguinaria canadensis. The synergistic interaction between eugenol and Sanguinarine was found to exhibit moderate cytotoxicity against MCF-7 cell lines, with an IC50 value of 147.2 µM, suggesting potential anti-cancer properties. The combination also demonstrated potent antioxidant activity, comparable to quercetin, in DPPH and H2O2 scavenging assays. The results suggest that the eugenol-Sanguinarine combination may have therapeutic applications in the prevention and treatment of oxidative stress-related diseases and cancer. Further studies are needed to fully elucidate the mechanisms of action and optimal dosing regimens. Overall, this study highlights the potential of combining natural compounds to create novel antioxidant and anti-cancer agents, and underscores the importance of continued research into the therapeutic properties of plant-derived compounds.
Cite this article:
Vikas Sharma, Sandeep Kumar, Rahul Kaushik, Shaivi Parashar. Synergistic Anticancer and Antioxidant effects of Eugenol and Sanguinarine: A Novel Phytochemical Combination. Research Journal of Pharmacy and Technology. 2025;18(9):4409-4. doi: 10.52711/0974-360X.2025.00632
Cite(Electronic):
Vikas Sharma, Sandeep Kumar, Rahul Kaushik, Shaivi Parashar. Synergistic Anticancer and Antioxidant effects of Eugenol and Sanguinarine: A Novel Phytochemical Combination. Research Journal of Pharmacy and Technology. 2025;18(9):4409-4. doi: 10.52711/0974-360X.2025.00632 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-9-52
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