ABSTRACT:
Stability indicating RP-UPLC method for the simultaneous estimation of TEL and AZEL in bulk and its pharmaceutical dosage form. In RP-UPLC method, chromatographic separation was achieved using C18 column (100 × 2.1mm, 1. 7µm) and Water-Methanol-FA (70: 30: 0.1) as mobile phase at flow rate of 0.4ml/min with detection wavelength of 243 nm. The linearity of both TEL and AZEL were found in the range of 20-60µg/ml and 4-8µg/ml. Retention time in RP-UPLC method were found to be 1.63 min, 1.15min for TEL and AZEL respectively. The % recovery were found to be 99.47±99.88 for TEL and 99.17±100.20% for AZEL. The proposed method was validated as per ICH guidelines and successfully applied for the determination of drugs in pharmaceutical formulation. This evaluation supported the method’s environmental friendliness regarding solvent usage, chemical substances, energy consumption, and waste generation.
Cite this article:
Suresh Kumar, Nirma Chavda. Stability Indicating RP-UPLC Method for the Simultaneous Estimation of Telmisaran and Azelnidipine in bulk and its Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2025;18(9):4083-7. doi: 10.52711/0974-360X.2025.00586
Cite(Electronic):
Suresh Kumar, Nirma Chavda. Stability Indicating RP-UPLC Method for the Simultaneous Estimation of Telmisaran and Azelnidipine in bulk and its Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2025;18(9):4083-7. doi: 10.52711/0974-360X.2025.00586 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-9-6
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