ABSTRACT:
The present research aims to develop and evaluate chlorzoxazone-loaded transdermal patches for the effective management of muscle spasms. These patches serve as an alternative to conventional oral dosage forms, which are often linked to systemic adverse effects. Chlorzoxazone, a centrally acting skeletal muscle relaxant, is widely prescribed to alleviate muscle pain and stiffness. However, oral administration frequently results in gastrointestinal irritation and inconsistent plasma drug concentrations. Transdermal drug delivery systems offer a promising approach by enabling sustained drug release and reducing systemic toxicity. In this study, different polymer combinations were utilized to optimize drug release and enhance skin permeability. The patches were fabricated using the solvent evaporation method, with varying concentrations of chlorzoxazone, polymers, plasticizers, and penetration enhancers. The prepared patches were evaluated for their mechanical and physicochemical properties, including thickness, weight uniformity, drug content, and in vitro release profile. Results indicated uniformity in thickness, weight, and drug loading, ensuring dose consistency. In vitro diffusion studies demonstrated a sustained release of chlorzoxazone for up to 12 hours. Overall, the developed chlorzoxazone transdermal patches represent a potential substitute for oral therapy, providing prolonged drug delivery and improved patient compliance.