Author(s):
Iffath Rizwana, Syed Tabraiz Ullah Hussaini, Javeria Fathima
Email(s):
tabraizullah96@gmail.com
DOI:
10.52711/0974-360X.2026.00044 
Address:
Iffath Rizwana1, Syed Tabraiz Ullah Hussaini2*, Javeria Fathima3
1Professor, Department of Pharmaceutical Analysis and Quality Assurance, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad-500001, Telangana, India.
2Assistant Professor, Department of Pharmaceutical Analysis and Quality Assurance, Sultan-Ul-Uloom College of Pharmacy. Mount Pleasant, Banjara Hills Road number 3, Hyderabad-500034, Telangana, India.
3Student of M. Pharmacy, Department of Pharmaceutical Analysis and Quality Assurance, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad-500001, Telangana, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 1,
Year - 2026
ABSTRACT:
This study presents a detailed RP-HPLC method for quantifying Atoltivimab (ALT), Maftivimab (MFT), and Odesivimab (ODE) in the Inmazeb injection formulation. Using an Inertsil column and a 50:50 isocratic mobile phase of sodium bisulfate and acetonitrile, the flow rate was maintained at 1.0 ml/min. Detection and quantification were performed simultaneously at 236 nm. Retention times (RT) for ALT, MFT, and ODE were approximately 2.7, 3.9, and 6.2 minutes, respectively, with a linear concentration range of 8.33–25 µg/ml. The Detection limit (LOD) for ALT, MFT, and ODE were 0.050 µg/ml, 0.100 µg/ml, and 0.088 µg/ml, while the limits of quantification (LOQ) were 0.185 µg/ml, 0.333 µg/ml, and 0.293 µg/ml, respectively.
Cite this article:
Iffath Rizwana, Syed Tabraiz Ullah Hussaini, Javeria Fathima. Stability Indicating RP-HPLC Method for Simultaneous Assay of Atoltivimab, Odesivimab and Maftivimab in a Combined Parenteral Dosage form. Research Journal of Pharmacy and Technology. 2026;19(1):308-2. doi: 10.52711/0974-360X.2026.00044
Cite(Electronic):
Iffath Rizwana, Syed Tabraiz Ullah Hussaini, Javeria Fathima. Stability Indicating RP-HPLC Method for Simultaneous Assay of Atoltivimab, Odesivimab and Maftivimab in a Combined Parenteral Dosage form. Research Journal of Pharmacy and Technology. 2026;19(1):308-2. doi: 10.52711/0974-360X.2026.00044 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-1-44
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