ABSTRACT:
This study investigates the cardioprotective effects of herbonanoceutical from Hibiscus surattensis L. leaf extract (HSL) against isoproterenol-induced myocardial damage in diabetic animals. This study was an experimental study using thirty-three male Sprague Dawley rats which were randomly divided into five groups. Diabetes induction was carried out with streptozotocin 50 mg/kg BW and nicotinamide 120 mg/kg ip. On the seventh to fourteenth days, treatment was given according to the group with concurrent isoproterenol (85 mg/kg ip) administration on day 13 and 14. Diabetic mice with myocardial infarction showed altered injury markers, increased lipid peroxidation in the myocardium, and elevated glucose and liver enzymes. Moreover, increased pro-in?ammatory markers and histological severity were observed. The results obtained indicate that the herbonanoceutical HSL has the potential as a glucose-lowering agent, especially at a dose of 50 mg/kg BW, and also exhibits cardioprotective potential as a protective agent against heart damage, as demonstrated by its ability to reduce heart biomarkers (CK, CK-MB, LDH, SGOT, SGPT) in disease conditions, approaching the levels seen in healthy controls. Based on these findings, the herbonanoceutical HSL appears to be a promising new target as an adjuvant therapy to treat complications of diabetes and other related conditions.