Author(s):
Amora M. Abou-El-Naga, Saad S Al-Dujaily, Ahmed Badawy, Sura B. Sharafaldeen
Email(s):
ss_mash_2022@yahoo.com
DOI:
10.52711/0974-360X.2026.00056 
Address:
Amora M. Abou-El-Naga1, Saad S Al-Dujaily2, Ahmed Badawy3, Sura B. Sharafaldeen1,4
1Zoology Department, Mansoura University, Egypt.
2High Institute for Infertility Diagnosis and ART-Al-Nahrain University, Baghdad, Iraq.
3Collage of Medicine, Mansoura University, Egypt.
4The University of Mashreq, Baghdad, Iraq.
*Corresponding Author
Published In:
Volume - 19,
Issue - 1,
Year - 2026
ABSTRACT:
The growth and maturation of the follicles and oocytes are influenced by many reproductive hormones and growth factors which in turn interfere with the success of fertilization and conception. We assessed the serum and follicular fluid levels of Progesterone, Prostaglandin E2 hormones, and Amphiregulin Growth factor on the day of ova pick-up and embryo transfer using enzyme-linked immunosorbent assay (ELISA). The result showed highly significant differences were encountered between PCOS and non-PCOS groups, serum (P4, PGE2, AREG) on the day of ova pickup (OPU), follicular (P4, PGE2, AREG) on the day of ova pickup (OPU) and embryo transfer (ET), All these variables were significantly (P<0.001) higher in non- PCOS groups in comparison with PCOS group. Conclusion: 1. Women with PCOS had significantly less serum and follicular fluid amount of Progesterone, Prostaglandin, and Amphiregulin growth factor than non-Pcos 2. Amphiregulin can be used as a predictor for increasing the successful pregnancy rate in IVF or ICSI protocol 3. Very strong positive correlation between AREG, PGE2, and P4 in serum and follicular fluid
Cite this article:
Amora M. Abou-El-Naga, Saad S Al-Dujaily, Ahmed Badawy, Sura B. Sharafaldeen. Role of Amphiregulin Growth Factor, Progesterone Hormone with Prostaglandin on Successful Implantation in PCOS Women Undergoing ICSI. Research Journal of Pharmacy and Technology. 2026;19(1):382-9. doi: 10.52711/0974-360X.2026.00056
Cite(Electronic):
Amora M. Abou-El-Naga, Saad S Al-Dujaily, Ahmed Badawy, Sura B. Sharafaldeen. Role of Amphiregulin Growth Factor, Progesterone Hormone with Prostaglandin on Successful Implantation in PCOS Women Undergoing ICSI. Research Journal of Pharmacy and Technology. 2026;19(1):382-9. doi: 10.52711/0974-360X.2026.00056 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-1-56
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