Author(s):
Chandra Kant Bhardwaj, Sana Rafi, Shailey Singhal, Abhilasha Mishra, Amar Nath
Email(s):
drckb2012@gmail.com
DOI:
10.52711/0974-360X.2026.00086 
Address:
Chandra Kant Bhardwaj1*, Sana Rafi2, Shailey Singhal3, Abhilasha Mishra4, Amar Nath5
1Department of Chemistry, Graphic Era Hill University, Dehradun, Uttarakhand, 248002 India.
2Department of Geography, HNB Garhwal University SRT Campus Tehri Uttarakhand, India.
3Applied Science Cluster, School of Advanced Engineering, UPES, Dehradun, Uttarakhand, 248007, India.
4Department of Chemistry, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, 248002 India.
5Department of Mathematics, COER University, Roorkee, Uttarakhand, 247667, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
Alprazolam with a molar solution of metallic nitrate has reacted to generate the complexes of Mn (II) and Cr (III). The molar solution of metallic nitrate and ligand (AP) was mixed in a 1:1 ratio. The complex formation takes place at room temperature. “The complexes have the predicted formula [(L)M(NO3)2], [(L)M(NO3)3] where M = Mn (II) and Cr (III) and L = AP “[Alprazolam]”. Bidentate and tridentate metal complexes were observed to have "N (1)" and "N (4)" positions on the ligands. An elemental analysis of complexes restricted to their stoichiometry. In the study, AP (alprazolam) and its complexes were examined against selected bacteria and fungi for their antimicrobial properties. Metal complexes showed greater antimicrobial activity than alprazolam in the current study.
Cite this article:
Chandra Kant Bhardwaj, Sana Rafi, Shailey Singhal, Abhilasha Mishra, Amar Nath. Synthesis, Characterization and Antimicrobial Studies of Mn(II) and Cr(III) Ion Metal Complexes with Alprazolam Drug. Research Journal of Pharmacy and Technology. 2026;19(2):589-3. doi: 10.52711/0974-360X.2026.00086
Cite(Electronic):
Chandra Kant Bhardwaj, Sana Rafi, Shailey Singhal, Abhilasha Mishra, Amar Nath. Synthesis, Characterization and Antimicrobial Studies of Mn(II) and Cr(III) Ion Metal Complexes with Alprazolam Drug. Research Journal of Pharmacy and Technology. 2026;19(2):589-3. doi: 10.52711/0974-360X.2026.00086 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-2-15
REFERENCES:
1. Schallek W, Horst WD, Schlosser W. Mechanisms of Action of Benzodiazepines. Vol. 16, Advances in Pharmacology. 1979; 45–87p. https://doi.org/10.1016/S1054-3589(08)60242-2.
2. Mandrioli R, Mercolini L, Augusta Raggi M. Metabolism of Benzodiazepine and Non-Benzodiazepine Anxiolytic-Hypnotic Drugs: an Analytical Point of View. Current Drug Metabolism. 2010 Nov 1; 11(9): 815–29. https://doi.org/10.2174/138920010794328887.
3. Brandelli A, Bizani D, Martinelli M, Stefani V, Gerbase AE. Antimicrobial activity of 1,4-naphthoquinones by metal complexation. Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences. 2004; 40(2): 247–53. https://doi.org/10.1590/s1516-93322004000200014
4. Ferrari MB, Fava GG, Tarasconi P, Albertini R, Pinelli S, Starcich R, et al. Synthesis , Spectroscopic and Structural Characterization, and Biological Activity of Aquachloro (Pyridoxa1 thiosemicarbazone ) Copper @) Chloride. 1994; 25: 13–25.
5. Bhardwaj CK, Talniya NC, Mishra A, Singh VP, Rafi S. Synthesis, Spectral, Chromatographic and Antimicrobial Studies of Transition Metal Complexes of Chromium (III) and Cobalt (II) Ions with Alprazolam Drug. Research Journal of Pharmacy and Technology. 2024; 17(7): 3213-7.
6. Bhardwaj CK, Kumari A, Singh A. The Physico-Chemical and Solvolytic Study of Alprazolam Drug in Ethanol at 303 K. Oriental Journal of Chemistry. 2014; 30(2): 843.
7. Choudhury MH, Chakraborty R, Raychaudhuri U. D Iscovery. 2014; 12(29): 24–32.
8. Hossain S, Zakaria CM. Structural and biological activity studies on metal complexes containing thiosemicarbzone and isatin based schiff base: a review. Asian Journal of Research in Chemistry. 2017; 10(1): 6-13. http://dx.doi.org/10.5958/0974-4150.2017.00002.5
9. Prakash BS, Raj CI, Raj GA. Synthesis and Characterization of Bio Active Transition Metal Complexes of Cu (II) Co (II) and Ni (II) using Natural Sources. Asian Journal of Research in Chemistry. 2015; 8(12): 726. https://doi.org/10.5958/0974-4150.2015.00117.0
10. Bhardwaj CK, Prakash S, Bhardwaj AK. Study of nitrazepam interaction with alcohol: An ultrasonic and physiochemical investigation. Canadian Journal of Chemistry. 2021; 99(12): 942–9. https://doi.org/10.1139/cjc-2021-0042.
11. Olson EJ, Bühlmann P. Getting more out of a job plot: Determination of reactant to product stoichiometry in cases of displacement reactions and n: N complex formation. Journal of Organic Chemistry. 2011; 76(20): 8406–12. https://doi.org/10.1021/jo201624p.
12. Isherwood I. Book reviews. In: Brain. 1991. p. 2016–7. https://doi.org/10.1093/brain/114.4.2016-b.
13. Abramson IJ, Smibert RM. Method of testing antibiotic sensitivity of spirochaetes, using antibiotic discs. The British journal of venereal diseases. 1972; 48(4): 269–73. https://doi.org/10.1136/sti.48.4.269.
14. Nakamoto K, Fujita J, Murata H. Infrared Spectra of Metallic Complexes. V. The Infrared Spectra of Nitro and Nitrito Complexes. Journal of the American Chemical Society. 1958; 80(18): 4817–23. https://doi.org/10.1021/ja01551a016.
15. Basavaraju B, Bhojya Naik HS, Prabhakara MC. Transition metal complexes of quinolino[3,2-b]benzodiazepine and quinolino[3,2-b]benzoxazepine: Synthesis, characterization, and antimicrobial studies. Bioinorganic Chemistry and Applications. 2007; 2007(Ii). https://doi.org/10.1155/2007/42587.
16. Sharma VK, Srivastava S. Template synthesis and structural characterization of homo binuclear chromium (III), manganese(III), iron(III), cobalt(III), and ruthenium (III) complexes with octaazamacrocyclic ligands. Turkish Journal of Chemistry. 2006; 30(6): 755–67.
17. Latha R, Umadevi M. Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Sulfonamide Drug. Journal of Advanced Applied Scientific Research. 2017; 1(9). https://doi.org/10.46947/joaasr19201772.
18. Abdul-Hassan MM, Mousa NK. Antimicrobial activity of new transition metal complexes of sulfamethoxazole on nhibiter by Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi and Escherichia coli. AIP Conference Proceedings. 2020; 2290. https://doi.org/10.1063/5.0027486.
19. Nair R, Shah A, Baluja S, Chanda S. Synthesis and antibacterial activity of some Schiff base complexes. Journal of the Serbian Chemical Society. 2006; 71(7): 733–44. https://doi.org/10.2298/JSC0607733N.
20. Panda KC, Kumar BV, Sahoo BM. Microwave Induced Synthesis of 1, 2, 4-triazole derivatives and Study of their Anthelmintic and Anti-microbial Activities. Research Journal of Pharmacy and Technology. 2022; 15(12): 5746-50.. https://doi.org/10.52711/0974-360X.2022.00969.
21. Al-Mosawi SK, Al-Hazam HA, Abbas AF. Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde. Asian Journal of Research in Chemistry. 2019; 12(3): 153-6. http://dx.doi.org/10.5958/0974-4150.2019.00031.2
22. Sahu S, Upadhyay PK, Mishra P. Evaluation of Antimicrobial potential of some Novel sulphonamido-4-thiazolidinone analogues on clinical strains of bacteria and fungi. Research Journal of Pharmacy and Technology. 2023; 16(6): 2668-74. https://doi.org/10.52711/0974-360X.2023.00438
23. Al-Mosawi SK, Al-Hazam HA, Abbas AF. Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde. Asian Journal of Research in Chemistry. 2019; 12(3): 153-6. http://dx.doi.org/10.5958/0974-4150.2019.00031.2
24. Sukanya P, Reddy CV. Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2 (1H)-one and 2-hydroxy-3-methoxybenzaldehyde. Asian Journal of Research in Chemistry. 2017; 10(1): 54-7. http://dx.doi.org/10.5958/0974-4150.2017.00010.4
25. Senwar RC, Rathore KK, Mehta A. Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides. Asian Journal of Research in Chemistry. 2017; 10(2): 135-41. http://dx.doi.org/10.5958/0974-4150.2017.00022.0
26. Prabhakar V, Venkateswarlu B, Bhargavi P, Jagadeesh S. Design, Synthesis and Activity of Novel Quinazoline Derivatives Linked with various Sulphonamides. Asian Journal of Research in Chemistry. 2016; 9(10): 485.
27. Murugavel S, Deepa S, Ravikumar C, Ranganathan R, Alagusundaram P. Synthesis, structural, spectral and antibacterial activity of 3,3a,4,5-tetrahydro-2H-benzo[g]indazole fused carbothioamide derivatives as antibacterial agents. Journal of Molecular Structure. 2020; 1222. https://doi.org/10.1016/j.molstruc.2020.128961.
28. Thimmaiah KN, Lloyd WD, Chandrappa GT. Stereochemistry and fungitoxicity of complexes of p-anisaldehydethiosemicarbazone with Mn(II), Fe(II), Co(II) and Ni(II). Inorganica Chimica Acta. 1985; 106(2): 81–3. https://doi.org/10.1016/S0020-1693(00)82252-5.
29. Khan SA, Nami SAA, Bhat SA, Kareem A, Nishat N. Synthesis, characterization and antimicrobial study of polymeric transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II). Microbial Pathogenesis. 2017; 110: 414–25. Available from: http://dx.doi.org/10.1016/j.micpath.2017.07.008