Author(s):
Sameh Fawzy Elsonbaty, Mohammad Chand Jamali, Wadah M.A Khogali, Hend Hamed, Mohamed Abdelfatah Abdelmounim Mohamed, Maxime Merheb, Adham Elsonbaty, Rehab Mohd Jamali
Email(s):
sameh.elsonbaty@lu.ac.ae , mjamali68@gmail.com , maxime.merheb@dmu.ae , wadah.khogali@lu.ac.ae , hend.ahmad@lu.ac.ae , mohammed.abdelfatah@lu.ac.ae , samsonbaty@gmail.com , rehab.jamali@gmail.com
DOI:
10.52711/0974-360X.2026.00175 
Address:
Sameh Fawzy Elsonbaty1, Mohammad Chand Jamali2*, Wadah M.A Khogali1, Hend Hamed1, Mohamed Abdelfatah Abdelmounim Mohamed2, Maxime Merheb3, Adham Elsonbaty4, Rehab Mohd Jamali5
1Department of Health & Laboratory Sciences, College of Medical and Health Sciences, Liwa University, Abu Dhabi, United Arab Emirates.
2Department of Health & Laboratory Sciences, College of Medical and Health Sciences, Liwa University, Al Ain, Abu Dhabi, United Arab Emirates.
3College of Health Sciences, Dubai Medical University, Dubai, United Arab Emirates
4Faculty of Medicine, October 6 University, Egypt.
5College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
The growing reliance on diagnostic X-ray imaging has raised concerns regarding its potential effects on cellular and tissue health. This research explores the impact of diagnostic X-ray exposure on the structural integrity of blood vessels, with a special focus on the aortic wall in rats. We analyzed the aorta's ultrastructural changes using electron microscopy by comparing patients exposed to X-rays to a control group. The findings revealed significant alterations in the aortic wall, including changes in the smooth muscle cells, elastic fibres, basal lamina, collagen deposition, and intracellular structures. These findings suggest that diagnostic X-ray exposure may disrupt the structural components of the aorta, potentially contributing to long-term vascular damage.
Cite this article:
Sameh Fawzy Elsonbaty, Mohammad Chand Jamali, Wadah M.A Khogali, Hend Hamed, Mohamed Abdelfatah Abdelmounim Mohamed, Maxime Merheb, Adham Elsonbaty, Rehab Mohd Jamali. Impact of Diagnostic X-Ray Exposure on Blood Vessel Integrity in Albino Rats: An Electron Microscopy Analysis. Research Journal Pharmacy and Technology. 2026;19(3):1230-4. doi: 10.52711/0974-360X.2026.00175
Cite(Electronic):
Sameh Fawzy Elsonbaty, Mohammad Chand Jamali, Wadah M.A Khogali, Hend Hamed, Mohamed Abdelfatah Abdelmounim Mohamed, Maxime Merheb, Adham Elsonbaty, Rehab Mohd Jamali. Impact of Diagnostic X-Ray Exposure on Blood Vessel Integrity in Albino Rats: An Electron Microscopy Analysis. Research Journal Pharmacy and Technology. 2026;19(3):1230-4. doi: 10.52711/0974-360X.2026.00175 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-36
REFERENCE:
1. Yoon CW, Park HK, Rha JH. Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke. Eur Neurol. 2018; 80(5-6): 245-248. doi: 10.1159/000496373.
2. Berman M, et al. Co-culture systems and radiation biology: bridging in vitro and in vivo. Front Physiol. 2022; 13: 900235. doi:10.3389/fphys.2022.900235.
3. Ping Z, Peng Y, Lang H, Xinyong C, Zhiyi Z, Xiaocheng W, Hong Z, Liang S. Oxidative Stress in Radiation-Induced Cardiotoxicity. Oxid Med Cell Longev. 2020 Mar 1; 2020: 3579143. doi: 10.1155/2020/3579143.
4. Jahng JWS, Little MP, No HJ, Loo BW Jr, Wu JC. Consequences of ionizing radiation exposure to the cardiovascular system. Nat Rev Cardiol. 2024 Dec; 21(12): 880-898. doi: 10.1038/s41569-024-01056-4.
5. Harrison D, Lowe S, Patel H. In vivo models for studying radiation-induced vascular permeability and endothelial dysfunction. Radiat Res. 2020; 194(2): 168-176. doi:10.1667/RR2018.2.
6. Johnson LA, et al. Diagnostic X-rays and their impact on vascular integrity. Clin Imaging. 2018;52:12–19..
7. Ponce SB, Seldon C, Yanagihara TK, Horowitz D, Yu JB, Kachnic L, et al. Crazy busy: The blurring of personal and professional boundaries as a diversity, equity, and inclusion issue. Int J Radiat Oncol Biol Phys. 2023; 116(2): 276–9. http://dx.doi.org/10.1016/j.ijrobp.2023.01.010
8. Lavin LM. Radiography in veterinary technology. 5th ed. Elsevier; 2013
9. Lopez CL, Zhang Z, Shen C. Advanced 3D in vitro models to study radiation effects on endothelial cells: innovations and challenges. J Biomed Sci. 2021; 28: 75. doi:10.1186/s12929-021-00091-2.
10. Marin J, et al. Molecular mechanisms of endothelial barrier regulation after radiation. Cell Rep. 2019 Oct 22; 29(4): 1027-1037.
11. Huda W, Abrahams RB. Radiographic techniques, contrast, and noise in x-ray imaging. AJR Am J Roentgenol [Internet]. 2015; 204(2): W126-31. Available from: http://dx.doi.org/10.2214/AJR.14.13116
12. Potts PJ. X-RAY FLUORESCENCE AND EMISSION | wavelength dispersive X-ray fluorescence. In: Encyclopedia of Analytical Science. Elsevier; 2005. p. 419–29.
13. Fritz S, Chaitow L, Hymel GM. Review of pertinent anatomy and physiology. In: Clinical Massage in the Healthcare Setting. Elsevier; 2008. p. 140–95.
14. Watanabe M, et al. Protocol for electron microscopy of rat aortic tissue. Microscopy Techniques. 2015; 22(2): 115–121.
15. Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11. doi: 10.1042/BST20060007.
16. Yang X, Zhang H, Wu L. The role of immune response in radiation-induced vascular damage: implications for therapy. J Clin Invest. 2023; 133(1): e154230. doi:10.1172/JCI154230.
17. Zhao W, Li Y, Sun H. Epidemiological evidence on radiation exposure and cardiovascular disease risk among atomic bomb survivors. Circ Res. 2022; 130(4): 498-510. doi:10.1161/CIRCRESAHA.121.318013.