Author(s):
Sayyad Sakinabee Reshma Begum, Saritha Damineni, Anupama Koneru, P. Subhash Chandra Bose
Email(s):
daminenisaritha@yahoo.co.in , sayyadreshmabegum@gmail.com
DOI:
10.52711/0974-360X.2026.00193 
Address:
Sayyad Sakinabee Reshma Begum1, Saritha Damineni1*, Anupama Koneru1, P. Subhash Chandra Bose2
1Sultan ul Uloom College of Pharmacy, Banjara Hills, Hyderabad, Telangana, India.
2MNR College of Pharmacy, Sangareddy, Telangana, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
The design of gastro-retentive floating tablets increases gastric residence time, enhancing the solubility and bioavailability of poorly soluble drugs while enabling prolonged drug release. Objective: The aim of the present study was to formulate Silymarin floating tablets capable of withstanding stomach acidity and providing sustained drug release. Methods: Silymarin gastro-retentive floating tablets were prepared and evaluated for preformulation parameters, in vitro buoyancy, drug content, and in vitro drug release. Results: All formulations exhibited acceptable preformulation characteristics. The formulation containing HPMC K100 (S6) was identified as the optimized formulation, achieving 99.43% drug release over 12 hours. Conclusion: The optimized formulation (S6) demonstrated effective buoyancy with a floating lag time of less than 30 seconds and sustained drug release for over 12 hours, making it a promising candidate for gastro-retentive drug delivery.
Cite this article:
Sayyad Sakinabee Reshma Begum, Saritha Damineni, Anupama Koneru, P. Subhash Chandra Bose. Formulation and In Vitro Evaluation of Silymarin Gastro Retentive Floating Tablets. Research Journal Pharmacy and Technology. 2026;19(3):1346-0. doi: 10.52711/0974-360X.2026.00193
Cite(Electronic):
Sayyad Sakinabee Reshma Begum, Saritha Damineni, Anupama Koneru, P. Subhash Chandra Bose. Formulation and In Vitro Evaluation of Silymarin Gastro Retentive Floating Tablets. Research Journal Pharmacy and Technology. 2026;19(3):1346-0. doi: 10.52711/0974-360X.2026.00193 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-54
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