Author(s):
P.R.Kiresee Saghana, S. Shanmugavani, R. Priya, P. Amudha, V.Dhivya
Email(s):
kireseesaghana.sls@velsuniv.ac.in
DOI:
10.52711/0974-360X.2026.00195 
Address:
P.R.Kiresee Saghana1*, S. Shanmugavani2, R. Priya2, P. Amudha3 and V.Dhivya4
1Assistant Professor Department of Bioinformatics, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
2Assistant Professor Department of Bioinformatics, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
3Assistant Professor Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai - 600117, Tamil Nadu, India.
4Assistant Professor Department of Civil Engineering, Vels Institute of Science and Technology in Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, representing approximately 90% of all liver cancer cases and is the second leading cause of cancer-related deaths. Hepatitis B virus (HBV) infection is the primary risk factor for HCC, responsible for about 70-80% of HCC cases in India and around 55% worldwide. This study aims to identify bioactive compounds that can counteract Hepatitis B infection. The human hepatitis B capsid protein (1QGT), a key protein involved in the malignant transformation process, was selected for virtual screening with various phytochemical compounds from different plants. Following virtual screening and pharmacokinetic analysis using Swiss ADME and admetSAR, 16 compounds were shortlisted and docked with the target protein using AutoDock Vina. The docking results were compared to Tenofovir. The analysis indicated that the compounds 4,7-Methanofuro[3,2-c] oxacycloundecin-6(4H) one (-8.7kcal/mol) and Luvangetin (-8.1kcal/mol) are potential inhibitors of the Human Hepatitis B viral capsid protein.
Cite this article:
P.R.Kiresee Saghana, S. Shanmugavani, R. Priya, P. Amudha, V.Dhivya. In-Silico Approach Based Identification of Potential Bioactive Compounds from Phytochemicals as Inhibitors of Hbv- Mediated Hepatocellular Carcinoma. Research Journal Pharmacy and Technology. 2026;19(3):1357-4. doi: 10.52711/0974-360X.2026.00195
Cite(Electronic):
P.R.Kiresee Saghana, S. Shanmugavani, R. Priya, P. Amudha, V.Dhivya. In-Silico Approach Based Identification of Potential Bioactive Compounds from Phytochemicals as Inhibitors of Hbv- Mediated Hepatocellular Carcinoma. Research Journal Pharmacy and Technology. 2026;19(3):1357-4. doi: 10.52711/0974-360X.2026.00195 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-56
REFERENCES:
1. Mefenamic Acid. In Drugs.com. (2023). https://www.drugs.com/mtm/mefenamic-acid.html
2. Mazumder S, Bindu S, Debsharma S, Bandyopadhyay U. Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these wonder drugs. Biochemical Pharmacology. 2024,May.13: 116283, DOI:https://doi.org/10.1016/j.bcp.2024.116283
3. Ali KA, Maity A, Roy SD, Pramanik SD, Das PP, Shaharyar MA. Insight into the mechanism of steroidal and non-steroidal anti-inflammatory drugs. InHow Synthetic Drugs Work 2023 Jan 1 (pp. 61-94). DOI: 10.1016/B978-0-323-99855-0.00004-X
4. S. Marakatham, P. Shanmugapandiyan. Bioanalytical Method Development and Validation of Doravirine, Lamavudine and Tenofovir Disoproxil Fumarate using HPLC in Human Plasma. Research Journal of Pharmacy and Technology. 2021; 14(8):4087-1. DOI :10.52711/0974-360X.2021.00708
5. . Dibya Das, Dhiman Halder, Himangshu Sekhar Maji, Pintu Kumar De, Tapan Kumar Pal. Special Emphasis on Bioanalytical Method Development and Validation of an Anti-Hypertensive Drug Azelnidipine by LC-ESI-MS/MS in Healthy Human Volunteer’s Blood Plasma. Research Journal of Pharmacy and Technology. 2021; 14(7): 3571-7 Doi:10.52711/0974-360X.2021.00618
6. Gurumurthy. Telugu, P. V. Suresh. Bioanalytical Method Development and Validation of Eprosartan Mesylate and Hydrochlorthiazide using RP-HPLC in Human plasma. Research Journal of Pharmacy and Technology 2023; 16(3): 1095-9. DOI:10.52711/0974-360X.2023.00182
7. K. Bhavyasri, B. Aishwarya, D. Suchitra, M. Sumakanth. Spectrometric Bioanalytical Method Development and Validation of Tolvaptan in Spiked Human plasma Followed by Forced degradation Studies. Research Journal of Pharmacy and Technology. 2023; 16(12): 5996-1. DOI: 10.52711/0974-360X.2023.00973