Author(s):
Zainab Lokhandwala, Fahim Khan, Ritam Moitra, Vishwa Desai, Abbas Ali Tinwala, S P Srinivas Nayak
Email(s):
sp.nayak19810@paruluniversity.ac.in
DOI:
10.52711/0974-360X.2026.00210 
Address:
Zainab Lokhandwala1, Fahim Khan1, Ritam Moitra1, Vishwa Desai1, Abbas Ali Tinwala2, S P Srinivas Nayak3
1Department of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, India.
2CFA (Charter Financial Analyst) Level 3 Candidate, CFA Institute.
3Assistant Professor, Department of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Background: This study aims to explore the underlying mechanisms that link obesity to the progression of breast cancer as well as the incidence of breast cancer in obese folks. Breast cancer, one of the many devastating cancers, is yet another formidable adversary against which obesity stands as a significant risk factor. Several molecular pathways– chronic inflammation, hormonal dysregulation, and metabolic anomalies are involved in the relationship involving obesity and breast cancer. The primary objective is to determine the prevalence of breast cancer in obese patients and to evaluate the influence of obesity on type of breast cancer, for which, we collected a total of 102 patients and analysed in our retro-prospective observational study. Results: The study discovered that majority of women suffering from breast cancer fell within the age spectrum of 41 to 50 years and beyond, with a high prevalence among perimenopausal and menopausal women, which was further demonstrated by Chi square test of independence (p value = 0.0000224 < 0.05). Our study also revealed that there is a noteworthy association between elevated BMI and the occurrences of breast cancer (p value = 0.00001 < 0.05). We also discovered that elevated BMI influences the type of breast cancer that has occurred, which was manifested by the application of Proportional analysis (Estrogen positive breast cancer = 0.605) Majority of the subjects were obese and pre-obese conjugatively. A majority (81.3%) had comorbidities, while 11.76% had addictive behaviours. Genetic variables were involved; a notable 6.86% of individuals with a hereditary predisposition to breast cancer, predominantly inherited it from their mothers. 66% cases were of invasive ductal carcinomas. Estrogen-positive cases were the most frequent subtype (59.77%). Stage IV breast cancer commonly metastasized to the lungs and bones. Conclusion: The conclusion of the study pours light on how obesity can be a risk factor of breast cancer. We also concluded that obesity could influence the type of breast cancer and estrogen-positive breast cancer appeared to be the major type caused by obesity. Age and consequently menstrual phase also associate with the occurrence of breast cancer in folks, perimenopausal and menopausal females being the most vulnerable to get affected by this ailment.
Cite this article:
Zainab Lokhandwala, Fahim Khan, Ritam Moitra, Vishwa Desai, Abbas Ali Tinwala, S P Srinivas Nayak. Tipping The Scales: The Impact of Obesity on Prevalence of Breast Cancer. Research Journal Pharmacy and Technology. 2026;19(3):1459-5. doi: 10.52711/0974-360X.2026.00210
Cite(Electronic):
Zainab Lokhandwala, Fahim Khan, Ritam Moitra, Vishwa Desai, Abbas Ali Tinwala, S P Srinivas Nayak. Tipping The Scales: The Impact of Obesity on Prevalence of Breast Cancer. Research Journal Pharmacy and Technology. 2026;19(3):1459-5. doi: 10.52711/0974-360X.2026.00210 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-71
8. REFERENCES:
1. Cancer-Its various types along with causes, symptoms, treatments and stages, in: cancer info guide, 2009. http://www.cancer-info-guide.com/ (15 Mar. 2010).
2. EL-Ashmawy NE, EL-Zamarany EA, F. Khedr N, M. Selim H, G. Khedr E. New Shining Stars in The Sky of Breast Cancer Diagnosis and Prognosis: A Review. Research Journal of Pharmacy and Technology. 2022; 3808–13. http://dx.doi.org/10.52711/0974-360x.2022.00639
3. Madhavi Boddupalli B, Ramani R, Mung’oma M, Muraga M, Nath Anisetti R, Nemala A. Common Edible Essential oils with strong potential against Breast Cancer and their Mechanisms. Research Journal of Pharmacy and Technology. 2023; 477–80 http://dx.doi.org/10.52711/0974-360x.2023.00081
4. Iyengar NM, Zhou XK, Gucalp A, Morris PG, Howe LR, Giri DD, et al. Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer. Clinical Cancer Research [Internet]. 2016 May 1; 22(9): 2283–9. http://dx.doi.org/10.1158/1078-0432.ccr-15-2239
5. Iyengar NM, Gucalp A, Dannenberg AJ, Hudis CA. Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation. Journal of Clinical Oncology [Internet]. 2016 Dec 10; 34(35): 4270–6. http://dx.doi.org/10.1200/jco.2016.67.4283
6. Lago F, Dieguez C, Gómez-Reino J, Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine & Growth Factor Reviews [Internet]. 2007 Jun; 18(3–4): 313–25. http://dx.doi.org/10.1016/j.cytogfr.2007.04.007
7. Rose D, Gracheck P, Vona-Davis L. The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers [Internet]. 2015 Oct 26; 7(4): 2147–68. http://dx.doi.org/10.3390/cancers7040883
8. Rose DP, Vona‐Davis L. Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer. BioFactors [Internet]. 2013; Jul 16; 40(1): 1–12. http://dx.doi.org/10.1002/biof.1109
9. Crespi E, Bottai G, Santarpia L. Role of inflammation in obesity-related breast cancer. Current Opinion in Pharmacology [Internet]. 2016 Dec; 31: 114–22. http://dx.doi.org/10.1016/j.coph.2016.11.004
10. Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, et al. Increased Levels of COX-2 and Prostaglandin E2 Contribute to Elevated Aromatase Expression in Inflamed Breast Tissue of Obese Women. Cancer Discovery [Internet]. 2012 Apr 1; 2(4): 356–65. http://dx.doi.org/10.1158/2159-8290.cd-11-0241
11. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. The Lancet Oncology [Internet]. 2010 Jun; 11(6): 530–42. http://dx.doi.org/10.1016/s1470-2045(10)70095-4
12. Lopez R, Arumugam A, Joseph R, Monga K, Boopalan T, Agullo P, et al. Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin/IGF1R signaling and activation of AKT/mTOR. PLoS ONE. (2013) 8: e79708.
13. Rose DP, Vona-Davis L. The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression. Endocrine-Related Cancer [Internet]. 2012 Aug 30; 19(6): R225–41. http://dx.doi.org/10.1530/erc-12-0203
14. Simone V, D’Avenia M, Argentiero A, Felici C, Rizzo FM, De Pergola G, et al. Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications. The Oncologist [Internet]. 2016 Feb 10; 21(4): 404–17. http://dx.doi.org/10.1634/theoncologist.2015-0351
15. Khan S, Shukla S, Sinha S, Meeran SM. Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets. Cytokine & amp; Growth Factor Reviews [Internet]. 2013 Dec; 24(6): 503–13. http://dx.doi.org/10.1016/j.cytogfr.2013.10.001
16. Nagaraju GP, Rajitha B, Aliya S, Kotipatruni RP, Madanraj AS, Hammond A, et al. The role of adiponectin in obesity-associated female-specific carcinogenesis. Cytokine & Growth Factor Reviews [Internet]. 2016 Oct; 31: 37–48. http://dx.doi.org/10.1016/j.cytogfr.2016.03.014
17. Grossmann ME, Cleary MP. The balance between leptin and adiponectin in the control of carcinogenesis – Focus on mammary tumorigenesis. Biochimie [Internet]. 2012 Oct; 94(10): 2164–71. http://dx.doi.org/10.1016/j.biochi.2012.06.013
18. Chung SJ, Nagaraju GP, Nagalingam A, Muniraj N, Kuppusamy P, Walker A, et al. ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy [Internet]. 2017 Jul 11; 13(8): 1386–403. http://dx.doi.org/10.1080/15548627.2017.1332565
19. Widschwendter P, Friedl TW, Schwentner L, DeGregorio N, Jaeger B, Schramm A, et al. The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial. Breast Cancer Research [Internet]. 2015 Sep 18; 17(1). http://dx.doi.org/10.1186/s13058-015-0639-3
20. Münzberg H, Björnholm M, Bates SH, Myers MG. Leptin receptor action and mechanisms of leptin resistance. Cellular and Molecular Life Sciences [Internet]. 2005 Mar; 62(6). http://dx.doi.org/10.1007/s00018-004-4432-1
21. Ray A. Adipokine leptin in obesity-related pathology of breast cancer. Journal of Biosciences [Internet]. 2012 Apr 3; 37(2): 289–94. http://dx.doi.org/10.1007/s12038-012-9191-9
22. Barone I, Giordano C, Bonofiglio D, Andò S, Catalano S. Leptin, obesity and breast cancer: progress to understanding the molecular connections. Current Opinion in Pharmacology [Internet]. 2016 Dec; 31: 83–9. http://dx.doi.org/10.1016/j.coph.2016.10.003
23. Pérez-Pérez A, Vilariño-Garcia T, Fernández-Riejos P, Martín-González J, Segura-Egea JJ, Sánchez-Margalet V. Role of leptin as a link between metabolism and the immune system. Cytokine & Growth Factor Reviews [Internet].2017 Jun; 35: 71–84. http://dx.doi.org/10.1016/j.cytogfr.2017.03.001
24. Wu MH, Chou YC, Chou WY, Hsu GC, Chu CH, Yu CP, et al. Circulating levels of leptin, adiposity and breast cancer risk. British Journal of Cancer [Internet]. 2009 Feb; 100(4): 578–82. http://dx.doi.org/10.1038/sj.bjc.6604913
25. Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer [Internet]. 2012 Apr; 1825(2): 207–22. http://dx.doi.org/10.1016/j.bbcan.2012.01.002
26. Khabaz MN, Abdelrahman A, Butt N, Damnhory L, Elshal M, Aldahlawi AM, et al. Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer. BMC Women’s Health [Internet]. 2017 Nov 9; 17(1). http://dx.doi.org/10.1186/s12905-017-0459-y
27. Andò S, Gelsomino L, Panza S, Giordano C, Bonofiglio D, Barone I, et al. Obesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms. Cancers [Internet]. 2019 Jan 9; 11(1): 62. http://dx.doi.org/10.3390/cancers11010062
28. Blanquer-Rosselló M del M, Oliver J, Sastre-Serra J, Valle A, Roca P. Leptin regulates energy metabolism in MCF-7 breast cancer cells. The International Journal of Biochemistry & amp; Cell Biology [Internet]. 2016 Mar; 72: 18–26. http://dx.doi.org/10.1016/j.biocel.2016.01.002
29. Ahima RS, Osei SY. Leptin signaling. Physiology & amp; Behavior [Internet]. 2004 Apr; 81(2): 223–41. http://dx.doi.org/10.1016/j.physbeh.2004.02.014
30. Newman G, Gonzalez-Perez RR. Leptin–cytokine crosstalk in breast cancer. Molecular and Cellular Endocrinology [Internet]. 2014 Jan; 382(1): 570–82. http://dx.doi.org/10.1016/j.mce.2013.03.025
31. Zheng Q, Banaszak L, Fracci S, Basali D, Dunlap SM, Hursting SD, et al. Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocrine-Related Cancer [Internet]. 2013 Sep 11; 20(6): 797–808. http://dx.doi.org/10.1530/erc-13-0329
32. Gérard C, Brown KA. Obesity and breast cancer – Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue. Molecular and Cellular Endocrinology [Internet]. 2018 May; 466: 15–30. http://dx.doi.org/10.1016/j.mce.2017.09.014
33. Raut PK, Choi DY, Kim SH, Hong JT, Kwon TK, Jeong JH, et al. Estrogen receptor signaling mediates leptin-induced growth of breast cancer cells via autophagy induction. Oncotarget [Internet]. 2017 Nov 25; 8(65): 109417–35. http://dx.doi.org/10.18632/oncotarget.22684
34. Wang X, Simpson ER, Brown KA. Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer. The Journal of Steroid Biochemistry and Molecular Biology [Internet]. 2015 Sep; 153: 35–44. http://dx.doi.org/10.1016/j.jsbmb.2015.07.008
35. Jayashree V, Velraj M. Breast Cancer and various Prognostic Biomarkers for the diagnosis of the disease: A Review. Research Journal of Pharmacy and Technology. 2017; 10(9): 3211. http://dx.doi.org/10.5958/0974-360x.2017.00570.4
36. RA Hajare, KS Parwani, SA Bajad, NA. Chandekar, AVChandewar. Breast Cancer and Indole -3-Carbinol: Controversy of Estrogen Level and Enzyme Elastase. Research J. Pharm. and Tech. 2009; 2 (3): July-Sept. 439-440.
37. Sinha VB, Pandey N, Taneja P. Biomarker genes for gynaecological cancers. Research Journal of Pharmacy and Technology [Internet]. 2016; 9(10): 1641. http://dx.doi.org/10.5958/0974-360x.2016.00329.2
38. Hussein TA, Tamemi IAA. Micro RNA 145 as Biomarker for Breast cancer. Research Journal of Pharmacy and Technology. 2019; 12(12): 5923. http://dx.doi.org/10.5958/0974-360x.2019.01027.8
39. Alrubaye YSJ, Mohammed MB, Abdulamir HA. Exosome and Breast Cancer. Research Journal of Pharmacy and Technology. 2022; 1393–7. Available from: http://dx.doi.org/10.52711/0974-360x.2022.00232
40. Cao Y, Xia B, Zhang Z, Hu D, Huang X, Yuan J, et al. Association of Body Fat Distribution and Risk of Breast Cancer in Pre- and Postmenopausal Women. Obesity Facts [Internet]. 2023; 16(4): 356–63. http://dx.doi.org/10.1159/000529834
41. Pati S, Irfan W, Jameel A, Ahmed S, Shahid RK. Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management. Cancers [Internet]. 2023 Jan 12;15(2):485. http://dx.doi.org/10.3390/cancers15020485
42. Hariramani N, Jayanthi S. A Systematic Review of Intrinsic Factors and its Influence in Breast Cancer. Research Journal of Pharmacy and Technology. 2018; 11(8): 3543. http://dx.doi.org/10.5958/0974-360x.2018.00654.6
43. Asaad RA. Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh-Syria. Research Journal of Pharmacy and Technology. 2017; 10(9): 3003. http://dx.doi.org/10.5958/0974-360x.2017.00532.7
44. Dimauro I, Grazioli E, Antinozzi C, Duranti G, Arminio A, Mancini A, et al. Estrogen-Receptor-Positive Breast Cancer in Postmenopausal Women: The Role of Body Composition and Physical Exercise. International Journal of Environmental Research and Public Health [Internet]. 2021 Sep 18; 18(18): 9834. http://dx.doi.org/10.3390/ijerph18189834
45. Stark A, Schultz D, Kapke A, Nadkarni P, Burke M, Linden M, et al. Obesity and risk of the less commonly diagnosed subtypes of breast cancer. European Journal of Surgical Oncology (EJSO) [Internet]. 2009 Sep; 35(9): 928–35. http://dx.doi.org/10.1016/j.ejso.2008.11.009
46. Rose DP, Vona-Davis L. Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas [Internet]. 2010 May; 66(1): 33–8. http://dx.doi.org/10.1016/j.maturitas.2010.01.019
47. Yi M, Ryu YM. The Effects of Breast Health Education in Women with Breast Cancer. Research Journal of Pharmacy and Technology. 2017; 10(7): 2295. http://dx.doi.org/10.5958/0974-360x.2017.00407.3