ABSTRACT:
The solubility of the active substance in the preparation base determines the level of the active substance that can reach the target cells. Many active drug substances have a low level of solubility in body solvents. In fact, the solubility property is a requirement for the active substance to work in side effects. Ketoprofen (KPN) is a BCS Class II drug compound that has a very low level of solubility in water, which is 0.010mg/ml. Dengen bark extract (EKBD) also has low solubility in water because contain active compounds that are lipophilic (insoluble in water) or hydrophobic, which can be difficult to dissolve in conventional solvents. This study aims to help the solubility of KPN and EKBD in solvents other than organic solvents. The method used is to use the Deep Eutecticum Solvents (DESs) system, namely a binary mixture of fatty acids and menthol, namely Lauric Acid, Stearic Acid, Palmitic Acid, Myristic Acid with the concentration ratio between fatty acids and menthol is 1:1, 0.25:1, 0.5:1, 2:1, 1:2, 1:0.5, 1:0.25. Characterization is carried out including the level of solubility using a UV Vis spectrophotometer; viscosity, determination of changes in functional groups using FTIR and XRD. The results showed a mixture of lauric acid and menthol at a concentration ratio of 1:1; 0.25:1; 0.5:1; 1:2 produces clear liquid at various temperatures. While mixtures of other types of fatty acid do not produce a clear solution, and even do not dissolve in each other. The results show that consecutively at ratio 1:1; 0.25:1; 0.5:1; 1:2 for KPN was 10, 02mg/mL (99,15%), 9, 53mg/mL (94,34%), 10, 04mg/mL (99,42%) dan 10, 67mg/mL (105,63%). While for EKBD was 6,92mg/mL (82,19%), 3,50mg/mL (41,51%), 6,77mg/L (80, 37%), 7,51mg/mL (89,14%). The viscosity value is in accordance with the provisions, and there is no change in the structure of functional groups either from measurements with FTIR and XRD. Based on the result, it can be concluded that the good binary mixture with KPN and EKBD both in formula 4 (lauric acid : menthol = 1:2).