Author(s):
Rohayati, Mukti Priastomo, Valentina Lumbantobing, Suci Nar Vikasari, Muhammad Yusuf, Qurrat Ul Ain, Neng Fisheri Kurniati, I Ketut Adnyana
Email(s):
adnyana@itb.ac.id , rohayati.tlm@staff.poltekkesbandung.ac.id
DOI:
10.52711/0974-360X.2026.00215 
Address:
Rohayati1,2, Mukti Priastomo3, Valentina Lumbantobing4, Suci Nar Vikasari5, Muhammad Yusuf6, Qurrat Ul Ain7, Neng Fisheri Kurniati1, I Ketut Adnyana1*
1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung Jl. Ganesha No. 10, Coblong District, Bandung City, West Java 40132.
2Department of Medical Laboratory Technology, Poltekkes Kemenkes Bandung, Jl. Babakan Loa No. 10, Pasirkaliki, Kecamatan Cimahi Utara, West Java 40514, Indonesia.
3Department of Pharmacology, Faculty of Pharmacy, Mulawarman University, Jl Kuaro, Gunung Kelua Main Campus, Samarinda, East Kalimantan 75117, Indonesia.
4Department of Fundamental Nursing, Faculty of Nursing, Universitas Padjadjaran, Jl. Raya Bandung Sumedang
KM 21, Hegarmanah, Jatinangor Campus, Sumedang Regency, West Java 45363, Indonesia.
5Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl Terusan Jenderal Sudirman, Cimahi 40533 West Java, Ind
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Background: Acute coronary syndrome (ACS), mainly caused by atherosclerosis, remains a major global health issue, leading to significant morbidity and mortality, including in Indonesia. Risk factors such as smoking, obesity, degenerative diseases, diabetes, and heart disease contribute to ACS. Effective prevention, early diagnosis, and management are essential for reducing its impact, with biomarkers playing a crucial role. Objective and Methods: This study investigated the relationship between ACS risk factors and biomarkers hs-CRP, Troponin I, and Interleukin-18 (IL-18) in adults from Bandung, Indonesia, divided into normal subjects (n=25), those with at least one risk factor (n=20), and ACS cases (n=23). Serum levels were measured using ELISA and analyzed via multivariate regression. Results: All risk factors together significantly affected hs-CRP, Troponin I, and IL-18. Age and random blood sugar (RBS) mostly influenced hs-CRP; age and BMI affected Troponin I; while diastolic pressure and cholesterol were linked to IL-18. IL-18 increased steadily across Groups (p<0.001), while CRP could not clearly differentiate normal and at-risk Groups. Troponin I rose mainly in ACS patients. The comparative indexes for hs-CRP were 1:1:5, Troponin I 1:1.25:140, and IL-18 1:7:10 across the three Groups, suggesting that even slight increases in IL-18 were linked to ACS risk. Conclusion: IL-18 is a promising biomarker for indicating atherosclerosis severity and the risk of acute coronary syndrome.
Cite this article:
Rohayati, Mukti Priastomo, Valentina Lumbantobing, Suci Nar Vikasari, Muhammad Yusuf, Qurrat Ul Ain, Neng Fisheri Kurniati, I Ketut Adnyana. Prognostic Potential of Interleukin - 18 in Acute Coronary Syndrome: A Comparative Biomarker Study. Research Journal of Pharmacy and Technology. 2026;19(4):1499-5. doi: 10.52711/0974-360X.2026.00215
Cite(Electronic):
Rohayati, Mukti Priastomo, Valentina Lumbantobing, Suci Nar Vikasari, Muhammad Yusuf, Qurrat Ul Ain, Neng Fisheri Kurniati, I Ketut Adnyana. Prognostic Potential of Interleukin - 18 in Acute Coronary Syndrome: A Comparative Biomarker Study. Research Journal of Pharmacy and Technology. 2026;19(4):1499-5. doi: 10.52711/0974-360X.2026.00215 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-4-4
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