Author(s):
Shubham Tikait, Subhranshu Panda, Swati Deshmukh, Vishal Rasve
Email(s):
shubhamtikait004@gmail.com
DOI:
10.52711/0974-360X.2026.00269 
Address:
Shubham Tikait1*, Subhranshu Panda2, Swati Deshmukh3, Vishal Rasve4
1Research Scholar, Jaipur National University (JNU), Jaipur, Rajasthan – 302017, India.
2Director, School of Pharmaceutical Sciences, Jaipur National University (JNU), Jaipur, Rajasthan - 302017.
3Principal, Shraddha Institute of Pharmacy (SIOPs), Washim, Maharashtra – 444505, India.
4Assistant Professor, Shri Amolak Jain Vidya Prasarak Mandal's, College of Pharmaceutical Science & Research Center, Kada, Beed, Maharashtra – 414202, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Enteric-coated nanoparticles represent a cutting-edge strategy to improve the bioavailability and therapeutic effectiveness of orally administered drugs. By shielding drugs from gastric degradation and enabling site-specific release in the intestine, these nanoparticles ensure controlled and efficient drug delivery. This review explores the pharmacokinetic benefits of enteric-coated nanoparticles, including enhanced solubility, improved intestinal permeability, and reduced first-pass metabolism. Their applications span diverse therapeutic areas, such as gastrointestinal disorders, peptide and protein drug delivery, nonsteroidal anti-inflammatory drugs (NSAIDs), and targeted antibiotic/probiotic therapies. Emerging trends in this field include the use of biodegradable polymer coatings, hybrid nanocarrier systems, and innovations in 3D printing and artificial intelligence-driven formulation design. Additionally, regulatory challenges and scale-up considerations are discussed to bridge the gap between research and clinical translation. As advancements continue, enteric-coated nanoparticles have the potential to transform oral drug delivery, improving patient adherence, optimizing therapeutic efficacy, and paving the way for future applications in personalized medicine.
Cite this article:
Shubham Tikait, Subhranshu Panda, Swati Deshmukh, Vishal Rasve. Advancements in Enteric Coated Nanoparticles for Improving Bioavailability of Poorly Soluble Drugs: A Comprehensive Study. Research Journal of Pharmacy and Technology. 2026;19(4):1869-4. doi: 10.52711/0974-360X.2026.00269
Cite(Electronic):
Shubham Tikait, Subhranshu Panda, Swati Deshmukh, Vishal Rasve. Advancements in Enteric Coated Nanoparticles for Improving Bioavailability of Poorly Soluble Drugs: A Comprehensive Study. Research Journal of Pharmacy and Technology. 2026;19(4):1869-4. doi: 10.52711/0974-360X.2026.00269 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-4-58
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