ABSTRACT:
The objective of this study was to develop an effective omeprazole mucoadhesive tablets with excellent mucoadhesive force using three mucoadhesive polymers namely hydroxyl lpropyl methyl cellulose, sodium carboxy methyl cellulose, carbolpol934p and water insoluble polymer ethyl cellulose which can be attached with the intestinal mucosa. Mucoadhesive tablets are coated with respective polymer and prepared them enteric coated tablets by coated with Eudragit L100. All the physical evaluations were carried out including Swelling index. Drug-polymer interaction study and Bioadhesive strength were also measure by using beef intestine in pH 6.5 and 7.8 phosphate buffer solution. Tablets were evaluated in three mediums like 0.1N HCl, pH 6.5 and 7.8 phosphate buffer solution. Sodium carboxy methyl cellulose showed above 90% release where carbopol934p provided slow release 99% over a period of 12hr. but Ethyl cellulose containing tablets showed <70% release and release was diffusion and erosion controlled and followed Zero order kinetics. Thus, the present study concluded that, Carbopol934p containing mucoadhesive tablets of Omeprazole pellets and Di-Omeprazole magnesium powder can be used for local action in the intestine as well as for Oral Controlled Release Drug Delivery.