ABSTRACT:
In the present investigation, antimutagenicity of Lawsonia Inermis leaf extract was studied using a battery of mutagenicity test systems such us micronucleus and chromosomal aberrations in swiss albino mice. This plant is widely used as a cosmetic agent to stain hair, skin and nails. Three groups of Swiss albino mice were selected randomly (group with cyclophosphamide only, group with Lawsonia Inermis leaf extract plus cyclophosphamide and group with Lawsonia Inermis leaf extract only). A Single intraperitonial treatment of different concentrations (i.e. 500, 1000 and 1500 mg/kg body weight) dose of Lawsonia Inermis leaf extract was given along with the well known mutagenic agent to the experimental group. On comparing the outcome of all three groups, experimental and group with Lawsonia Inermis leaf extract showed significant reduction in micronucleus formation and chromosomal aberration in bone marrow cells after 24 hrs of administration. So it can be conclude that Lawsonia Inermis leaf extract can reduce the mutagenic potential of cyclophosphamide.