ABSTRACT:
The Sida acuta, Sida cordifolia, Sida rhombifolia and Sida spinosa (Malvaceae) and are considered to be one of the most valuable drugs in Ayurvedic medicine. All the parts of these plants was highly useful and among them root seems to be much useful. Traditionally Sida species used as externally healing of wounds, skin ulcers, inflammation and internally used in treatment of fever, liver disorders, analgesic. The Sida species distributed throughout the tropical and sub-tropical regions of the world and all over India. The anti-inflammatory activity of Sida species root extract were evaluated by carrageenan induced rat edema model and analgesic activity was determined by acetic acid induced writhing method in mice. In the entire models, group I served as control, group II, III, IV and V received extract at the dose level of 200 mg / kg body weight respectively and group VI served as standard drug. The results revealed that hydroalcohol extract of Sida cordifolia roots possess potent anti-inflammatory and analgesic activity among the four Sida species.