Author(s): Krishna Veni Nagappan, Meyyanathan SN, Rajinikanth B Raja, Suresh Reddy, Jeyaprakash MR, Arunadevi S Birajdar, Suresh Bhojraj

Email(s): krisath@yahoo.com

DOI: Not Available

Address: Krishna Veni Nagappan*, Meyyanathan SN, Rajinikanth B Raja, Suresh Reddy, Jeyaprakash MR, Arunadevi S Birajdar and Suresh Bhojraj
Department of Pharmaceutical Analysis, J S S College of Pharmacy, Rocklands, Ootacamund-643 001 Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008


ABSTRACT:
A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Ambroxol Hydrochloride and Loratidine from pharmaceutical dosage forms. The method was carried out on a Phenomenex Gemini C18 (25 cm x 4.6 mm i.d., 5 µ) column with a mobile phase consisting of acetonitrile: 50mM Ammonium Acetate (50:50 v/v) at a flow rate of 1.0 mL/min. Detection was carried out at 255 nm. Hydrochlorthiazide was used as an internal standard. The retention time of Ambroxol Hydrochloride, Loratidine and Hydrochlorthiazide was 5.419, 15.549 and 3.202 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the estimation of these drugs in combined Pharmaceutical dosage forms.


Cite this article:
Krishna Veni Nagappan, Meyyanathan SN, Rajinikanth B Raja, Suresh Reddy, Jeyaprakash MR, Arunadevi S Birajdar, Suresh Bhojraj. A RP-HPLC Method for Simultaneous Estimation of Ambroxol Hydrochloride and Loratidine in Pharmaceutical Formulation. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 366-369.

Cite(Electronic):
Krishna Veni Nagappan, Meyyanathan SN, Rajinikanth B Raja, Suresh Reddy, Jeyaprakash MR, Arunadevi S Birajdar, Suresh Bhojraj. A RP-HPLC Method for Simultaneous Estimation of Ambroxol Hydrochloride and Loratidine in Pharmaceutical Formulation. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 366-369.   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2008-1-4-68


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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