ABSTRACT:
Most of the conventional drug delivery system for treating the anginal are not much effective as the drug do not reach the site of action in appropriate concentration. Thus an effective and safe therapy of this anginal disorder using specific drug delivery system is a challenging task to the pharmaceutical technologists. The objective of the present study was to develop hydrophilic polymer (HPMC) and hydrophobic polymer (Ethyl cellulose) based Nicorandil matrix sustained release tablet which can release the drug up to time of 24 hrs in predetermined rate. The formulation of Nicorandil matrix tablet was prepared by the polymer combination in order to get required theoretical release profile. The influence of hydrophilic and hydrophobic polymer and granulation technique on Nicorandil was studied. The formulated tablet were also characterized by physical and chemical parameters, The in-vitro release rate profile should the higher concentration of F2 polymer in tablet, the combination of hydrophilic and hydrophobic combination showed less result than use of alone. The in–vitro release data was well fit to Peppas and Hixon crowel release kinetics.