ABSTRACT:
A cream formulation of the methanolic extract of the leaves of plant Acacia nilotica (Fabaceae) was evaluated pharmaceutically as well as biologically for its wound healing property made by excision wound model. The methanolic extract of leaves was obtained by Soxhlet extraction and its medicated as well as non-medicated cream formulation is developed using bees wax, liquid paraffin, borax and water. Commercially available Vicco turmeric cream was used as a standard for this study. All three formulations were evaluated for various pharmaceutical parameters such as Rheological properties, stability, pH and external characters as well as biologically for its wound healing activity on excision wound made on albino rats. Albino rats were differentiated into control group, non-medicated cream group (group of rats with non-medicated cream) and medicated cream group (group of rats with medicated cream), standard (vicco turmeric cream). Results were found by comparing the wound contraction (in mm2 and in %) as well as period of epithalisation of medicated cream with that of control group, non-medicated cream group and vicco turmeric cream (as standard) and was found faster for medicated cream than control group and non medicated one.