ABSTRACT:
This study evaluated the feasibility of formulating nanoparticles containing L-Arginine Using chitosan as polymer cross linked with TPP in an attempt to increase the availability in blood stream and other RES organs. The study shows a biphasic pattern of initial burst effect and the remaining amount found to release in a sustained manner. L-Arginine loaded chitosan nanoparticles prepared by Ionotropic gelation were characterized by Scanning electron microscopy and Atomic force spectroscopy for surface morphology and size distribution of coated and uncoated nanoparticles was found to be 405 nm and 508 nm respectively. The mechanism by which drug is being released is non-Fickian (anomalous) solute diffusion mechanism, i.e. the drug release may be controlled by all diffusion, erosion and swelling. It is evident from the results that initial burst release is retarded or delayed due to adsorption of coating material. Animal imager study shows that the nanoparticles bound drug was relatively more effective in targeting drug to RES organs than the free drug by IV route of administration.