ABSTRACT:
The reasons for the relatively low bioavailability of conventional eye drops is their short precorneal contact time, drainage, frequent medication etc. gels have been successfully used to increase the mucosal contact time and also bioavailability of the drug. The aim of the present work is to formulate an ocular drug delivery system with a prolonged duration of action and with better patient compliance. This can be achieved by formulating insitu gel forming drug delivery system containing diclofenac potassium using gelrite.® deacetylated gellan gum. Studies carried out on the formulation include evaluations such as physicochemical evaluation, microbiological evaluation and biological evaluation. Results indicate that the formulation containing drug and gelrite showed a prolonged release pattern compared to conventional preparation. The formulation was non irritant and had a good gelling property and faster recovery from inflammation. So it can be concluded that insitu gel formulation of diclofenac potassium is an ideal approach for the better bioavailability and better patient compliance compared to conventional solutions.