ABSTRACT:
Peptic ulcer is manifested largely due to an alteration in lifestyle and diet. The antiulcer efficacy of the fresh juice of leaves of Pedalium murex on ethanol induced gastric lesions was investigated in our studies. This has been substantiated by ascertaining the content of total acid, acid volume, total protein, ulcer index and glutathione. Ulceration was induced in 36 hours fasted rats by the administration of 80 % ethanol (1ml/kg) orally. The reference standard (Famotidine, 3ml/100gm) and fresh juice of leaves of Pedalium murex in doses of 0.5, 1.0, 2.0ml/100gm was given to different groups, one hour before the administration of ethanol. A marked gastric mucosal lesion was observed with ethanol. A perceptible elevation in ulcer index, total acidity, acid volume, total protein and elevation of glutathione was observed. Pretreatment with fresh juice of leaves of Pedalium murex particularly at a dose of 2.0ml/100gm in a single schedule and 1.0ml/100gm for 15 and 30 days treatment annihilated these alterations and elevated the level of glutathione. Therefore the fresh juice of leaves of Pedalium murex could be regarded as a favorable antiulcerogen which could be attributed to its content of flavonoids and mucilage.