ABSTRACT:
The purpose of the present work was to develop and characterize an oral sustained release (SR) matrix tablet of Glucosamine sulphate (GS) by employing luctaman gum (xanthone gum) and xanulac gum (guar gum) as matrix materials. A wet granulation technique was employed to prepare matrix tablets by utilizing various concentrations (10, 15, 20, 25, and 30) in the ratio of 1:1 along with 750mg of GS. The granules were evaluated for Bulk density, Tapped density, Compressibility index and Angle of repose. The prepared tablets were evaluated for various physico-chemical parameters by official procedures. The invitro release studies of the matrix tablet were carried out in Phosphate buffer pH 1.2 and 6.8 for 12hrs. The granules showed satisfactory flow properties and compressibility. ?ll the tablet showed acceptable pharmacotechnical properties and complied within the specifications for tested parameters. The formulation F-IV (25% concentration) could extend the release up to 12hrs and the mechanism of drug was diffusion followed by erosion.