ABSTRACT:
Amoxicillin bi layer matrix tablets were prepared using cellulose acetate (CA) and cellulose acetate butyrate (CAB) as matrix polymers for the extended release of amoxicillin. The matrix tablets consists of one immediate release layer which release the drug immediately and one sustained release layer which release the drug for a prolonged period of time. The matrix tablets were prepared by direct compression method. The prepared matrix tablets were characterized for the physical properties, drug content, differential scanning calorimetry (DSC) and in vitro dissolution studies. The prepared matrix tablets were kept for accelerated stability study as per ICH guidelines for about 3 months. The prepared bi layer matrix tablets were showing good physical properties. The initial rapid drug release from the bi layer matrix tablets was observed. The drug release was extended up to 16 hours. Differential scanning calorimetric thermographs shows the stable nature of Amoxicillin tri-hydrate. The release kinetics study revealed that the prepared bi-layer matrix tablets were best fitted to the first order. All the formulations were best fitted to Higuchi model indicated that the drug release was diffusion controlled. The prepared matrix tablets were having high commercial application.