ABSTRACT:
The aim of present study was to develop colon targeted drug delivery system for Ketoprofen using natural polysaccharides such as guar gum and locust bean gum as carrier. Matrix and compression coated tablets of Ketoprofen were prepared using both the gums. All the formulations were evaluated for the hardness, % drug content, and subjected to in vitro drug release studies. The amount of Ketoprofen released from tablets at different time interval was estimated by UV visible spectrophotometer. Guar gum and locust bean gum matrix tablets released about 60 % and 80 % of the Ketoprofen, respectively, within 5 h of the dissolution study and failed to control the drug release in the physiological environment of stomach and small intestine. The tablets compression coated with 300mg of guar gum and locust bean gum released about 10 % and 4 % of Ketoprofen respectively within 5 h of the dissolution study. When the dissolution study was further continued in presence of rat caecal content medium, there was increase in release of Ketoprofen due to biodegradation of gum coat. The results of the study showed that compression coated Ketoprofen tablets with 300 mg of guar gum coat are most likely to provide targeting of Ketoprofen for local action in the colon owing to its minimal release in the first 5 h. Differential scanning calorimetry indicated no interaction between Ketoprofen and gums.