ABSTRACT:
Hyperlipidemia, including hypercholesterolemia and hypertriglyceridemia, is a major risk factor for the development of cardiovascular diseases. The search for new drugs able to reduce and or to regulate serum cholesterol and triacylglycerol levels has gained importance over the years, resulting in numerous reports on significant activities of natural agents. In this study we assessed the hypolipidemic potential of Chenopodium album Linn (Chenopodiaceae) on triton induced hyperlipidemic rats. Experimental rats were divided into six groups of five rats each: Normal control group (NCG), Hyperlipidemic control group (HCG), Hyperlipidemic group (HG), methanolic extract treated group (HGCaM), aqueous soluble treated group (HGCaAS) and aqueous insoluble treated group (HGCaAIS). The treatment was continued for 5 days with a view to see the effect of drug after 12h, 24h, 72h and 120h on lipid profile such as total cholesterol, plasma triglycerides, HDL-cholesterol and LDL etc. Methanolic extract and its fraction have significantly decreases the lipid parameter such as total cholesterol, plasma triglycerides, LDL- Cholesterol, Atherosclerosis Index (AI) etc. The results suggest the consumption of Chenopodium album Linn can be linked to a reduction in the risk of cardiovascular diseases.