ABSTRACT:
Transdermal drug delivery system is one of the novel routes for systemic delivery of drugs through the skin. The main barrier for systemic absorption of drug through the skin is the upper most layer of skin i.e. the stratum corneum. Glibenclamide is a sulfonylurea category of drug used in the treatment of type II diabetes. It is found that glibenclamide can be permeated through the skin but its permeation is low. Therefore its permeation was studied through the freshly excised rat abdominal skin as such and in presence of some penetration enhancers. Penetration enhancers are the substances that facilitate the absorption of drug through the skin by temporarily diminishing the impermeability of the skin. In the present study permeation enhancers have been used to increase the permeation of glibenclamide through the freshly excised rat abdominal skin. The permeation enhancers used are eucalyptus oil, menthol, ethyl acetate and oleic acid respectively .It is found that eucalyptus oil has more effect as compared to other enhancers used in the study. The results are reported in this article.