Author(s): AD Kajale, BV Bakade, MA Channawar, SR Gawande, RL Bakal, AV Chandewar


DOI: Not Available

Address: AD Kajale*, BV Bakade, MA Channawar, SR Gawande, RL Bakal and AV Chandewar
Department of Pharmaceutics P. Wadhwani College of Pharmacy Yavatmal. (M.S). 445001.
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010

Oral delivery of drugs to the colon is valuable in the treatment of diseases of colon (ulcerative colitis, Chron's disease, carcinomas and infections) whereby high local concentration can be achieved while minimizing side effects that occur because of release of drugs in the upper GIT or unnecessary systemic absorption. The simplest method for targeting of drugs to the colon is to obtain slower release rates or longer release periods by the application of thicker layers of conventional enteric coatings or extremely slow releasing matrices. Various pharmaceutical approaches to to colon targeted delivery system are a) covalent linkage of drug with carrier b) coating with polymers c) coating with pH sensitive polymers d) coating with biodegradable polymers. Colon targeted drug delivery system is of special importance in systemic delivery of protein and peptide drugs also important when delay in drug absorption require from therapeutic point of view in the treatment of nocturnal asthma, angina etc.

Cite this article:
AD Kajale, BV Bakade, MA Channawar, SR Gawande, RL Bakal, AV Chandewar. Colon Targeted Drug Delivery System – A Review. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 45-49.

AD Kajale, BV Bakade, MA Channawar, SR Gawande, RL Bakal, AV Chandewar. Colon Targeted Drug Delivery System – A Review. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 45-49.   Available on:


1)       M. K. Chourasia and S. K. Jain, “ Pharmaceutical approaches to colon targeted drug delivery systems ”, journal of Pharmaceutical Science, 6(1), (2003), 33-66.

2)       Hans Schreier, “ Drug targeting technology ”, (Physical, Chemical, Biological methods), Marcel Dekker,Inc, New York • Basel,( 2001), chapter 2, 1-19.

3)       Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, “ Modified Release Drug Delivery Technology ”, Marcel Dekker, Inc, New York • Basel, (2003), 217-222.

4)       Raffi, R., Franklin, W. and Cerniglia, C.E, “Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora”. Appl Environ Mivrobiol, 56 (1990), 2146-2151.

5)       Raffi, R., Franklin, W., Heflich R.H. and Cerniglia, C.E, “ Reduction of nitroaromatic compounds” by anaerobic bacteria isolated from the human intestinal tract. Appl Environ Mivrobiol 57 (1991), 962-968.

6)       Walker, R. and Ryan, A.J, “Some molecular parameters influencing rate of reduction of azo compounds” by intestinal microflora. Xenobiotica, 1 (1971), 483-486.

7)       Yang L, James SC, Joseph A. “ Colon-specific drug delivery: New approaches and in vitro/ in vivo evaluation”. International  Journal of Pharmacy 235 (2002)1-15.

8)       Schacht E, Gevaert A, El Refaie K, Koen M, Verstraete W, Adriaensens P, et al. “Polymers for colon specific drug delivery”. Journal of Control Release 39 (1996), 327-8.

9)       Wilding R, Davis SS, Pozzi F, Furlani P, Gazzaniga A. “Enteric coated timed release systems for colonic targeting”. International Journal of  Pharmacy 111,(1994) 99-102.

10)    Krishnaiah YS, Satyanarayana V, Dinesh Kumar B, Karthikeyan RS. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil. Eur J Pharm Sci 16, (2002), 185-92.

11)    Sinha VR, Rachna K. “ Polysaccharides in colon-specific drug delivery”. International Journal of Pharmacy 224, (2001), 19-38.

12)    Sinha VR, Rachna K. Coating polymers for colon specific drug delivery: A comparative in vitro evaluation. Acta Pharma 53, (2003), 41-7.

13)    Cavalcanti, OA, Van den Mooter G, Caramico-Soares I, Kinget R. “Polysaccharides as excipients for colon-specific coatings, permeability and swelling properties of casted films”. Drug Develop Ind Pharm 28, (2002) , 157-64.

14)    V Ravi, TM Pramod Kumar, Siddaramaiah, “Novel colon targeted drug delivery system using natural polymers”, Indian journal of pharmaceutical sciences, 70(1), (2008), 111-113.

15)    Wilding, I.R, Hardy, J.G. Sparrow, R.A., Davis, S.S, Daly, P.B. and English, J.R., In vivo evaluation of enteric coated naproxan tablets using gamma scintigraphy. Pharm Res, 9 (1992),1436-1441.

16)    Kimura, Y., Makita, Y., Kumagi, T., Yamane, T., Kiato, H., Sasatani, H. and Kim, S.I., “Degradation of azo-containg polyurethane by the action of intestinal flora: its metabolism and application as a drug delivery system”. Polymer, 33,(1992), 5294-5299.

17)    Ueda, T., Yamaoka, M., Miyamoto, M. and Kimura, Y., “Bacterial reduction of azo compounds as a model reaction for the degradation of azo-containing polyurethane by the action of intestinal flora”. Bull Chem Soc Jpn, 69 ,(1996) ,1139-1142.

18)    Yamaoka, T., Makita, Y., Sasatani, H., Kim, S.I. and Kimura, Y., Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behaviour, and utilization for drug formulation. J Control Rel, 66, (2000) , 187-97.

19)    Chavan, M.S., Sant, V.P. and Nagarsenker, M.S., Azo-containing urethane analogues for colonic drug delivery: synthesis, characterization and in-vitro evaluation. J Pharm Pharmacol, 53, (2001), 895-900.

20)    Vervoort, L. and Kinget, R., In vitro degradation by colonic bacteria of inulin HP incorporated in Eudragit RS films. Int J Pharm, 129,(1996), 185-190, 199

21)    Takashi Ishibashi, Kengo Ikegami, Hiroaki Kubo, Masao Kobayashi, Masakazu Mizobe, Hiroyuki Yoshino, “Evaluation of colonic absorbability of drugs in dogs using a novel colon-targeted delivery capsule (CTDC)”, Journal of Controlled Release 59 (1999) 361–376.


23) crohn’s diseases.


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available