Two novel, simple, sensitive, economical, accurate, rapid and precise spectrophotometric methods have been developed for the estimation of Cefditoren Pivoxil in pharmaceutical oral solid dosage form by spectrophotometry. Method A involves the determination of Cefditoren Pivoxil by Difference Spectrophotometry. It is based on shifting the l max by changing the pH of the solution (using 0.1M HCl and water). The absorption maximum was 275nm for drug in 0.1M HCl and 229nm for drug in water. The Beer’s concentration was found to be between 5-50 µg/mL . Method B involves determination of Cefditoren Pivoxil by Q-Absorbance method. This method depends on the property that, for a substance which obeys Beer’s law at all wavelengths, the ratio of absorbances at any two wavelengths is a constant value independent of concentration or pathlength. The wavelengths selected for this method are 232 nm and 275.6 nm. The methods have been statistically evaluated and were found to be precise and accurate. The proposed methods are economical and sensitive for the estimation of cefditoren pivoxil in bulk drug and formulations.
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