ABSTRACT:
Diabetes, the most prevailing metabolic disorder, is attracting present research attention towards it. In the present study, we have designed to evaluate the antihyperglycemic and antioxidant potential of Mehari choornam (POC), a poly herbal ayurvedic formulation, containing Curcuma longa, Emblica Officinalis and Syzigium cumini in different proportions as label claims. This combination of drug helps in reducing the blood glucose level in border-line diabetes and also acts as antioxidant thereby preventing end-organs complications. The effect of Mehari choornam on normoglycemic rats and on hyperglycemia induced with alloxan (120 mg/kg) on single and repeated administration of Mehari choornam was evaluated. The antioxidant potential of the extract was estimated in the heart and pancreas after repeated administration of Mehari choornam in alloxan induced diabetic rats. The results were satisfactory, as a significant decrease in the blood glucose levels after repeated administration was observed. The reversal of the decreased antioxidant enzyme levels in the heart and pancreatic tissues of diabetic rats suggest its efficacy against diabetes and oxidative damage.