ABSTRACT:
The recent pharmaceutical application multiparticulate dosage form are gaining much favour over single unit dosage form because of their potential benefit like predictable gastric empting , no risk of dose dumping, flexible release pattern and increase bioavaibility with less inter and intra subject variability. Captopril and Hydrochlorthizide have synergistic antihypertensive action act by inhibiting ACE, block the active reabsorption of sodium (Na+) and chloride (Cl-) with water in the distal tubule respectively. The controlled release multiparticulate drug delivery system was developed by using hydrophilic gums as release modifier polymers. The optimal therapeutic effect of the dosage form was developed using Captopril (t1/2- 1.9 hours) and Hydrochlorothide (t1/2- 6 to 15 hours). In the first step the influence of the combination of Xanthum gum, Karaya gum and Gaur gum on swelling and viscosity were investigated. The combination of Captopril and gum blend in ratio 1:1.5 and Hydrochlorthizide and gum in 1:0.5 ratios are optimized. In general, the release parameters shows that, two major factors control drug release from swelling controlled matrix systems, (i) the rate of aqueous medium infiltration into the matrix, followed by a relaxation process and (ii) the rate of matrix erosion. The controlled release and immediate release preparation are found by their dissolution profile.